通过氧化钯（II）催化实现无环烯烃的不对称分子间heck型反应。

Asymmetric intermolecular heck-type reaction of acyclic alkenes via oxidative palladium(II) catalysis.

作者信息

Yoo Kyung Soo, Park Chan Pil, Yoon Cheol Hwan, Sakaguchi Satoshi, O'Neill Justin, Jung Kyung Woon

机构信息

Loker Hydrocarbon Research Institute, Department of Chemistry, University of Southern California, Los Angeles, California 90089-1661, USA.

出版信息

Org Lett. 2007 Sep 27;9(20):3933-5. doi: 10.1021/ol701584f. Epub 2007 Aug 31.

DOI:10.1021/ol701584f

PMID:17760452

Abstract

Herein, we report an asymmetric intermolecular Heck-type reaction of acyclic alkenes by using a palladium-pyridinyl oxazoline diacetate complex under oxidative palladium(II) catalysis conditions. A premade palladium-ligand complex afforded higher enantioselectivities than a corresponding premixed palladium-ligand system, while offering enhanced asymmetric induction when compared to known intermolecular Heck-type protocols.

摘要

在此，我们报道了在氧化钯（II）催化条件下，使用钯 - 吡啶基恶唑啉二乙酸酯配合物实现无环烯烃的不对称分子间Heck型反应。与相应的预混合钯 - 配体体系相比，预制的钯 - 配体配合物具有更高的对映选择性，并且与已知的分子间Heck型反应方案相比，其不对称诱导作用增强。