Banerjee Birendranath, Vadiraj H S, Ram Amritanshu, Rao Raghavendra, Jayapal Manikandan, Gopinath Kodaganur S, Ramesh B S, Rao Nalini, Kumar Ajay, Raghuram Nagarathna, Hegde Sridevi, Nagendra H R, Prakash Hande M
Genome Stability Laboratory, Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Integr Cancer Ther. 2007 Sep;6(3):242-50. doi: 10.1177/1534735407306214.
Effects of an integrated yoga program in modulating perceived stress levels, anxiety, as well as depression levels and radiation-induced DNA damage were studied in 68 breast cancer patients undergoing radiotherapy. Two psychological questionnaires--Hospital Anxiety and Depression Scale (HADS) and Perceived Stress Scale (PSS)--and DNA damage assay were used in the study. There was a significant decrease in the HADS scores in the yoga intervention group, whereas the control group displayed an increase in these scores. Mean PSS was decreased in the yoga group, whereas the control group did not show any change pre- and postradiotherapy. Radiation-induced DNA damage was significantly elevated in both the yoga and control groups after radiotherapy, but the postradiotherapy DNA damage in the yoga group was slightly less when compared to the control group. An integrated approach of yoga intervention modulates the stress and DNA damage levels in breast cancer patients during radiotherapy.
在68名接受放射治疗的乳腺癌患者中，研究了综合瑜伽项目对感知压力水平、焦虑以及抑郁水平和辐射诱导的DNA损伤的影响。该研究使用了两份心理问卷——医院焦虑抑郁量表（HADS）和感知压力量表（PSS）——以及DNA损伤检测。瑜伽干预组的HADS评分显著降低，而对照组的这些评分有所增加。瑜伽组的平均PSS降低，而对照组在放疗前后未显示任何变化。放疗后，瑜伽组和对照组的辐射诱导DNA损伤均显著升高，但与对照组相比，瑜伽组放疗后的DNA损伤略少。综合瑜伽干预方法可调节乳腺癌患者放疗期间的压力和DNA损伤水平。
