Rosenthal Nadia, Brown Steve
Mouse Biology Unit, EMBL Monterotondo Outstation, via Ramarini 32, 00016, Monterotondo, Rome, Italy.
Nat Cell Biol. 2007 Sep;9(9):993-9. doi: 10.1038/ncb437.
The laboratory mouse is widely considered the model organism of choice for studying the diseases of humans, with whom they share 99% of their genes. A distinguished history of mouse genetic experimentation has been further advanced by the development of powerful new tools to manipulate the mouse genome. The recent launch of several international initiatives to analyse the function of all mouse genes through mutagenesis, molecular analysis and phenotyping underscores the utility of the mouse for translating the information stored in the human genome into increasingly accurate models of human disease.
实验小鼠被广泛认为是研究人类疾病的首选模式生物，它们与人类共享99%的基因。小鼠遗传实验有着卓越的历史，而强大的新型小鼠基因组操纵工具的开发更是进一步推动了这一领域的发展。最近启动的几项国际计划，旨在通过诱变、分子分析和表型分析来解析所有小鼠基因的功能，这凸显了小鼠在将人类基因组中存储的信息转化为越来越精确的人类疾病模型方面的效用。
