Vistamehr Setareh, Walsh Thomas J, Adelman Ron A
Yale University School of Medicine, Department of Ophthalmology and Visual Sciences, New Haven, CT 06520-8061, USA.
Semin Ophthalmol. 2007 Jul-Sep;22(3):141-6. doi: 10.1080/08820530701457134.
To describe the clinical features of ethambutol neuroretinopathy.
Case report and meta-analysis of the literature.
A patient with clinical and electrophysiological findings suggestive of ethambutol neuroretinopathy.
Electroretinogram, electro-oculogram and visual fields.
Clinical and electrophysiological findings.
101 cases were reviewed, retinal findings include retinal pigment epithelial changes, macular edema, flame-shaped hemorrhages. Electroretinogram findings include decreased amplitude and abnormal wave pattern in full field ERG, multifocal or pattern ERG and electro-oculogram findings include abnormal Arden ratio.
Clinical, electrophysiological and in vitro studies support the toxic effect of ethambutol on the retina. Therefore ethambutol ocular toxicity may be a neuroretinopathy.
描述乙胺丁醇所致神经视网膜病变的临床特征。
病例报告及文献荟萃分析。
一名具有提示乙胺丁醇神经视网膜病变临床及电生理表现的患者。
视网膜电图、眼电图及视野检查。
临床及电生理表现。
回顾了101例病例，视网膜表现包括视网膜色素上皮改变、黄斑水肿、火焰状出血。视网膜电图表现包括全视野视网膜电图、多焦或图形视网膜电图的波幅降低及波形异常，眼电图表现包括阿登比值异常。
临床、电生理及体外研究均支持乙胺丁醇对视网膜的毒性作用。因此，乙胺丁醇所致眼毒性可能是一种神经视网膜病变。
