Karrasch Thomas, Jobin Christian
Department of Medicine and the Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, USA.
Inflamm Bowel Dis. 2008 Jan;14(1):114-24. doi: 10.1002/ibd.20243.
The biological impact of the NF-kappaB transcriptional system in various intestinal biological processes such as cellular proliferation, differentiation and survival, inflammation, and carcinogenesis is a relatively young field of research. Less than a decade ago, reviews addressing NF-kappaB regulation and function in the intestine had to borrow concepts and hypotheses from other bodily systems such as the joints (rheumatoid arthritis), the lungs (asthma), or the cardiovascular system (systemic inflammatory states, sepsis). Since then, important progress has been made in defining the various functional aspects of NF-kappaB signaling in intestinal homeostasis and diseases, and exciting new paradigms have emerged from this research. This review will discuss the function of NF-kappaB in intestinal homeostasis and diseases in relation to injury responses and microbial colonization/infection.
核因子-κB转录系统在各种肠道生物学过程（如细胞增殖、分化和存活、炎症及致癌作用）中的生物学影响是一个相对较新的研究领域。不到十年前，关于肠道中核因子-κB调节和功能的综述还不得不借鉴其他身体系统（如关节（类风湿性关节炎）、肺（哮喘）或心血管系统（全身炎症状态、败血症））的概念和假说。从那时起，在确定核因子-κB信号在肠道稳态和疾病中的各种功能方面取得了重要进展，并且这项研究中出现了令人兴奋的新范例。本综述将讨论核因子-κB在肠道稳态和疾病中与损伤反应以及微生物定植/感染相关的功能。
