Panday Arvind, Inda Maria Eugenia, Bagam Prathyusha, Sahoo Malaya K, Osorio Diana, Batra Sanjay
Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, 70803, USA.
Department of Biological Sciences, Louisiana State University, Baton Rouge, LA, 70803, USA.
Arch Immunol Ther Exp (Warsz). 2016 Dec;64(6):463-483. doi: 10.1007/s00005-016-0405-y. Epub 2016 May 28.
The nuclear factor (NF)-κB family of transcription factors are ubiquitous and pleiotropic molecules that regulate the expression of more than 150 genes involved in a broad range of processes including inflammation, immunity, cell proliferation, differentiation, and survival. The chronic activation or dysregulation of NF-κB signaling is the central cause of pathogenesis in many disease conditions and, therefore, NF-κB is a major focus of therapeutic intervention. Because of this, understanding the relationship between NF-κB and the induction of various downstream signaling molecules is imperative. In this review, we provide an updated synopsis of the role of NF-κB in DNA repair and in various ailments including cardiovascular diseases, HIV infection, asthma, herpes simplex virus infection, chronic obstructive pulmonary disease, and cancer. Furthermore, we also discuss the specific targets for selective inhibitors and future therapeutic strategies.
核因子（NF）-κB转录因子家族是普遍存在且具有多效性的分子，可调节150多种基因的表达，这些基因参与包括炎症、免疫、细胞增殖、分化和存活等广泛过程。NF-κB信号的慢性激活或失调是许多疾病发病机制的核心原因，因此，NF-κB是治疗干预的主要焦点。正因为如此，了解NF-κB与各种下游信号分子诱导之间的关系势在必行。在本综述中，我们提供了NF-κB在DNA修复以及包括心血管疾病、HIV感染、哮喘、单纯疱疹病毒感染、慢性阻塞性肺疾病和癌症在内的各种疾病中的作用的最新概述。此外，我们还讨论了选择性抑制剂的具体靶点和未来的治疗策略。
