Neurath M F, Becker C, Barbulescu K
Laboratory of Immunology, I. Medical Clinic, University of Mainz, Langenbeckstrasse, 55101 Mainz, Germany.
Gut. 1998 Dec;43(6):856-60. doi: 10.1136/gut.43.6.856.
NF-kappaB is a pleiotropic transcription factor with key functions in the intestinal immune system. NF-kappaB family members control transcriptional activity of various promoters of proinflammatory cytokines, cell surface receptors, transcription factors, and adhesion molecules that are involved in intestinal inflammation. The perpetuated activation of NF-kappaB in patients with active inflammatory bowel disease suggests that regulation of NF-kappaB activity is a very attractive target for therapeutic intervention. Such strategies include antioxidants, proteasome inhibitors, inhibition of NF-kappaB by adenoviral I kappaB alpha expression vectors, and antisense DNA targeting of NF-kappaB. These approaches will hopefully permit the design of new treatment strategies for chronic intestinal inflammation.
核因子-κB是一种多效性转录因子，在肠道免疫系统中发挥关键作用。核因子-κB家族成员控制着参与肠道炎症的多种促炎细胞因子、细胞表面受体、转录因子和黏附分子启动子的转录活性。在活动性炎症性肠病患者中，核因子-κB的持续激活表明，调节核因子-κB活性是一个极具吸引力的治疗干预靶点。此类策略包括抗氧化剂、蛋白酶体抑制剂、通过腺病毒IκBα表达载体抑制核因子-κB，以及针对核因子-κB的反义DNA。这些方法有望为慢性肠道炎症设计出新的治疗策略。
