Larsen S, Kikinis R, Talos I-F, Weinstein D, Wells W, Golby A
Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Int J Med Robot. 2007 Sep;3(3):262-70. doi: 10.1002/rcs.149.
Mapping functional areas of the brain is important for planning tumour resections. With the increased use of functional magnetic resonance imaging (fMRI) for presurgical planning, there is a need to validate that fMRI activation mapping is consistent with the mapping obtained during surgery using direct electrocortical stimulation (DECS).
A quantitative comparison of DECS and fMRI mapping techniques was performed, using a patient-specific conductivity model to find the current distribution resulting from each stimulation site. The resulting DECS stimulation map was compared to the fMRI activation map, using the maximal Dice similarity coefficient (MDSC).
Our results show some agreement between these two mapping techniques--the stimulation site with the largest MOSC was the only site that demonstrated intra-operative effect.
There is a substantial effort to improve the techniques used to map functional areas, particularly using fMRI. It seems likely that fMRI will eventually provide a valid non-invasive means for functional mapping.
绘制大脑功能区对于规划肿瘤切除术很重要。随着功能磁共振成像（fMRI）在术前规划中的使用增加，有必要验证fMRI激活图谱是否与手术期间使用直接皮层电刺激（DECS）获得的图谱一致。
使用患者特异性电导率模型来确定每个刺激部位产生的电流分布，对DECS和fMRI图谱技术进行了定量比较。使用最大骰子相似系数（MDSC）将所得的DECS刺激图谱与fMRI激活图谱进行比较。
我们的结果表明这两种图谱技术之间存在一定的一致性——具有最大MDSC的刺激部位是唯一显示术中效应的部位。
人们正在大力改进用于绘制功能区的技术，特别是使用fMRI的技术。fMRI最终似乎有可能提供一种有效的非侵入性功能图谱绘制方法。
