Lupo Mary L, Cohen Joel L, Rendon Marta I
The Lupo Center for Aesthetic and General Dermatology, New Orleans, LA, USA.
J Drugs Dermatol. 2007 Jul;6(7):725-9.
Evidence of the signs associated with skin aging often first appears in the periorbital area and includes wrinkles, eyelid bags, circles around the eye, or a "tired" look. This multicenter study aimed to investigate a novel eye cream containing a proprietary mixture of human growth factors and cytokines in combination with caffeine, bisabolol, glycyrrhetinic acid, and sodium hyaluronate for periorbital rejuvenation. The study, which was completed by 37 female subjects between 36 to 65 years of age, revealed that clinical signs for wrinkles, lower eyelid bags or sagging, dark circles, and skin texture show significant improvement (average 14%-28%) after 6 weeks of twice-daily application. These clinical improvements were confirmed by a subject questionnaire. The subjects further reported that their tired look significantly improved by 32% in average. All subjects tolerated the eye cream well and liked the way it felt. The cream's efficacy, excellent tolerability in the delicate periorbital skin area, and pleasant sensory properties explain why a large majority (78%) would continue regular use.
皮肤老化相关迹象的证据通常首先出现在眼周区域，包括皱纹、眼袋、黑眼圈或“疲惫”外观。这项多中心研究旨在调查一种新型眼霜，其含有专利混合的人类生长因子和细胞因子，并结合了咖啡因、红没药醇、甘草次酸和透明质酸钠，用于眼周年轻化。该研究由37名年龄在36至65岁之间的女性受试者完成，结果显示，在每天早晚各使用一次、持续6周后，皱纹、下眼袋或下垂、黑眼圈以及皮肤质地的临床症状有显著改善（平均改善14%-28%）。这些临床改善通过受试者问卷得到证实。受试者进一步报告称，她们的疲惫外观平均显著改善了32%。所有受试者对该眼霜耐受性良好，且喜欢其使用感受。该眼霜的功效、在眼周娇嫩皮肤区域的出色耐受性以及宜人的感官特性，解释了为什么绝大多数（78%）受试者会继续经常使用。
