Brady Robert Thomas, Shah-Desai Sabrina
Department of Ophthalmology, Addenbrooke's Hospital, Cambridge, UK.
Perfect Eyes Ltd, London, UK.
J Cosmet Dermatol. 2025 Jul;24(7):e70326. doi: 10.1111/jocd.70326.
Hyperpigmentation and periorbital dark circles remain challenging dermatological concerns due to their multifactorial etiology, including vascular, pigmentary, and structural components. This study evaluates the efficacy of a novel multi-action topical formulation designed to target hyperpigmentation and skin aging through a synergistic blend of active ingredients.
To assess the objective and clinical effects of a dermatological composition containing niacinamide, arbutin, tranexamic acid, ubiquinone, a DHEA-like component, curcuma oily extract, and marine exopolysaccharides on periorbital hyperpigmentation and skin quality.
Subjects with visible under-eye dark circles applied the formulation twice daily over a treatment period of 6 weeks. The evaluation included instrumental quantitative assessments of skin pigmentation along with standardized imaging. A separate safety study and cosmetic efficacy questionnaire of patient experience were completed.
The formulation demonstrated statistically significant improvements in pigmentation intensity. The twice daily use of the under-eye serum resulted in an average overall reduction in under-eye hyperpigmentation of 47.94%, with no adverse effects observed.
This novel topical composition offers a safe and effective multi-targeted approach for improving periorbital hyperpigmentation and promoting overall skin rejuvenation. The synergistic action of its active components supports its use in clinical and aesthetic dermatology for the treatment of dark circles and age-related changes.
色素沉着和眶周黑眼圈因其多因素病因，包括血管、色素和结构成分，仍然是具有挑战性的皮肤病学问题。本研究评估了一种新型多效外用制剂的疗效，该制剂旨在通过活性成分的协同混合来针对色素沉着和皮肤老化。
评估一种含有烟酰胺、熊果苷、氨甲环酸、辅酶Q、一种类似脱氢表雄酮的成分、姜黄油性提取物和海洋胞外多糖的皮肤病学组合物对眶周色素沉着和皮肤质量的客观和临床效果。
有明显眼周黑眼圈的受试者在6周的治疗期内每天两次涂抹该制剂。评估包括对皮肤色素沉着的仪器定量评估以及标准化成像。还完成了一项单独的安全性研究和患者体验的美容功效问卷。
该制剂在色素沉着强度方面显示出统计学上的显著改善。每天两次使用眼周精华液使眼周色素沉着平均总体减少47.94%，未观察到不良反应。
这种新型外用组合物为改善眶周色素沉着和促进整体皮肤年轻化提供了一种安全有效的多靶点方法。其活性成分的协同作用支持其在临床和美容皮肤科用于治疗黑眼圈和与年龄相关的变化。
