Department of Neuropsychiatry, Fukushima Medical University, Fukushima, Japan.
Psychopharmacology (Berl). 2021 Jul;238(7):1781-1789. doi: 10.1007/s00213-021-05807-w. Epub 2021 Apr 7.
As a treatment for cognitive dysfunction in schizophrenia, oxytocin nasal sprays potentially improve social cognition, facial expression recognition, and sense of smell. Mismatch negativity (MMN) is an event-related potential (ERP) reflecting auditory discrimination while MMN deficits reflect cognitive function decline in schizophrenia.
To determine whether oxytocin nasal spray affects auditory MMN METHODS: We measured ERPs in healthy subjects during an auditory oddball task, both before and after oxytocin nasal spray administration. Forty healthy subjects were randomly assigned to either the oxytocin or placebo group. ERPs were recorded during the oddball task for all subjects before and after a 24 international unit (IU) intranasal administration, and MMN was compared between the two groups.
Participants who received oxytocin had significantly shorter MMN latencies than those who received a placebo. Oxytocin had no significant effect on the Change in MMN amplitude.
The shortened MMN latencies that were observed after oxytocin nasal spray administration suggest that oxytocin may promote the comparison-decision stage.
作为精神分裂症认知功能障碍的一种治疗方法，鼻喷催产素可能改善社会认知、面部表情识别和嗅觉。失匹配负波（MMN）是一种反映听觉辨别力的事件相关电位（ERP），而 MMN 缺陷反映了精神分裂症认知功能的下降。
确定鼻喷催产素是否影响听觉 MMN。
我们在健康受试者进行听觉Oddball 任务时测量了 ERP，分别在鼻喷催产素给药前后进行。40 名健康受试者被随机分配到催产素或安慰剂组。所有受试者在接受 24 国际单位（IU）鼻内给药前后的 Oddball 任务中记录了 ERP，并比较了两组之间的 MMN。
接受催产素的参与者的 MMN 潜伏期明显短于接受安慰剂的参与者。催产素对 MMN 振幅的变化没有显著影响。
鼻喷催产素给药后观察到的 MMN 潜伏期缩短表明，催产素可能促进了比较决策阶段。
