de Moraes Barros Marina Carvalho, Guinsburg Ruth, Mitsuhiro Sandro, Chalem Elisa, Laranjeira Ronaldo Ramos
Division of Neonatal Medicine at the Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
Early Hum Dev. 2008 May;84(5):281-7. doi: 10.1016/j.earlhumdev.2007.07.001. Epub 2007 Sep 4.
The Neonatal Intensive Care Unit Network Neurobehavioral Scale (NNNS) is used to assess neurological integrity, behavioral function and the existence of stress and abstinence signs in newborn infants.
To determine the neurobehavioral profile of healthy term neonates of adolescent mothers.
Cross-sectional study with prospective collection of data.
419 healthy newborns without analgesic/sedative use at labor, intra-uterine drug exposure, multiple gestation, congenital malformations or infections. The NNNS was applied with 33+/-7 hours of life in a quiet and dark room, between feedings.
Mean, SD, and 5th, 10th, 25th, 50th, 75th, 90th and 95th percentiles for each of 13 NNNS variables were determined and compared according to maternal age (12-14 years vs. 15-17 years vs. 18-19 years) by ANOVA.
Mothers had 17+/-1.5 years, 50% white, 7.1+/-2.2 years of education, prenatal care in 96%, vaginal delivery in 73%, and local/regional anesthesia in 75%. Neonates had birth weight 3205+/-299 g, gestational age 39.4+/-1.1 weeks, 55% male, 1 min Apgar 8.2+/-1.3, and 5 min Apgar 9.6+/-0.6. NNNS scores (mean+/-SD): habituation: 6.86+/-1.49; attention: 5.73+/-1.32; arousal: 3.70+/-0.70; regulation: 6.06+/-0.74; orientation handling procedures: 0.36+/-0.26; quality of movements: 5.11+/-0.49; excitability: 2.48+/-1.68; lethargy: 4.04+/-1.82; non-optimal reflexes: 3.67+/-1.35; asymmetry: 0.71+/-0.94; hypertonicity: 0.18+/-0.39; hypotonicity: 0.13+/-037; and stress/abstinence signs: 0.07+/-0.05. Infants of younger adolescent mothers were less lethargic than infants of older ones.
The description of the neurobehavioral profile of healthy term newborns of adolescent mothers is important to establish normal standards for this population.
新生儿重症监护病房网络神经行为量表（NNNS）用于评估新生儿的神经完整性、行为功能以及压力和戒断症状的存在情况。
确定青春期母亲所生健康足月儿的神经行为特征。
前瞻性收集数据的横断面研究。
419名健康新生儿，分娩时未使用镇痛/镇静药物，无宫内药物暴露、多胎妊娠、先天性畸形或感染。在安静、黑暗的房间里，两次喂奶之间，于出生33±7小时时应用NNNS。
确定13个NNNS变量各自的均值、标准差以及第5、10、25、50、75、90和95百分位数，并通过方差分析根据母亲年龄（12 - 14岁 vs. 15 - 17岁 vs. 18 - 19岁）进行比较。
母亲年龄为17±1.5岁，50%为白人，受教育年限7.1±2.2年，96%接受过产前护理，73%为阴道分娩，75%使用局部/区域麻醉。新生儿出生体重3205±299 g，胎龄39.4±1.1周，55%为男性，1分钟阿氏评分8.2±1.3，5分钟阿氏评分9.6±0.6。NNNS评分（均值±标准差）：习惯化：6.86±1.49；注意力：5.73±1.32；觉醒：3.70±0.70；调节：6.06±0.74；定向操作程序：0.36±0.26；运动质量：5.11±0.49；兴奋性：2.48±1.68；嗜睡：4.04±1.82；非最佳反射：3.67±1.35；不对称性：0.71±0.94；张力亢进：0.18±0.39；张力减退：0.13±0.37；压力/戒断症状：0.07±0.05。青春期较年轻母亲所生婴儿的嗜睡程度低于年龄较大母亲所生婴儿。
描述青春期母亲所生健康足月儿的神经行为特征对于建立该人群的正常标准很重要。
