Calabrese Edward J, Bachmann Kenneth A, Bailer A John, Bolger P Michael, Borak Jonathan, Cai Lu, Cedergreen Nina, Cherian M George, Chiueh Chuang C, Clarkson Thomas W, Cook Ralph R, Diamond David M, Doolittle David J, Dorato Michael A, Duke Stephen O, Feinendegen Ludwig, Gardner Donald E, Hart Ronald W, Hastings Kenneth L, Hayes A Wallace, Hoffmann George R, Ives John A, Jaworowski Zbigniew, Johnson Thomas E, Jonas Wayne B, Kaminski Norbert E, Keller John G, Klaunig James E, Knudsen Thomas B, Kozumbo Walter J, Lettieri Teresa, Liu Shu-Zheng, Maisseu Andre, Maynard Kenneth I, Masoro Edward J, McClellan Roger O, Mehendale Harihara M, Mothersill Carmel, Newlin David B, Nigg Herbert N, Oehme Frederick W, Phalen Robert F, Philbert Martin A, Rattan Suresh I S, Riviere Jim E, Rodricks Joseph, Sapolsky Robert M, Scott Bobby R, Seymour Colin, Sinclair David A, Smith-Sonneborn Joan, Snow Elizabeth T, Spear Linda, Stevenson Donald E, Thomas Yolene, Tubiana Maurice, Williams Gary M, Mattson Mark P
School of Public Health, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, USA.
Toxicol Appl Pharmacol. 2007 Jul 1;222(1):122-8. doi: 10.1016/j.taap.2007.02.015. Epub 2007 Mar 7.
Many biological subdisciplines that regularly assess dose-response relationships have identified an evolutionarily conserved process in which a low dose of a stressful stimulus activates an adaptive response that increases the resistance of the cell or organism to a moderate to severe level of stress. Due to a lack of frequent interaction among scientists in these many areas, there has emerged a broad range of terms that describe such dose-response relationships. This situation has become problematic because the different terms describe a family of similar biological responses (e.g., adaptive response, preconditioning, hormesis), adversely affecting interdisciplinary communication, and possibly even obscuring generalizable features and central biological concepts. With support from scientists in a broad range of disciplines, this article offers a set of recommendations we believe can achieve greater conceptual harmony in dose-response terminology, as well as better understanding and communication across the broad spectrum of biological disciplines.
许多经常评估剂量反应关系的生物学子学科已经确定了一个进化上保守的过程，即低剂量的应激刺激会激活一种适应性反应，从而增加细胞或生物体对中度至重度应激水平的抵抗力。由于这些众多领域的科学家之间缺乏频繁互动，出现了大量描述此类剂量反应关系的术语。这种情况已成为一个问题，因为不同的术语描述了一系列相似的生物学反应（例如，适应性反应、预处理、兴奋效应），对跨学科交流产生了不利影响，甚至可能模糊了可概括的特征和核心生物学概念。在众多学科科学家的支持下，本文提出了一系列建议，我们相信这些建议能够在剂量反应术语方面实现更大的概念一致性，并促进广泛生物学学科之间更好的理解和交流。
