Preston N W, Stanbridge T N
J Hyg (Lond). 1976 Apr;76(2):249-56. doi: 10.1017/s0022172400055145.
Type 1 strains of Bordetella pertussis can infect mouse brain and have been recovered as type 1 organisms after death. When introduced into the naso-pharynx of the marmoset, they immediately acquired agglutinogen 2 or 3, and the resulting type 1,2 or 1,3 infection persisted for many weeks. As in the child, agglutinogens 2 and/or 3 appear to be essential for infection of the marmoset, whereas they are quite unnecessary in mouse brain. A vaccine (extract or whole cell) containing agglutinogen 1 may be sufficient to pass the mouse protection test but it may fail to immunize children. The mouse test is inadequate even for the screening of such extracts.
百日咳博德特氏菌1型菌株可感染小鼠脑部，并在小鼠死后作为1型菌株被分离出来。将其接种于狨猴的鼻咽部后，它们立即获得凝集原2或3，由此产生的1,2型或1,3型感染可持续数周。与儿童一样，凝集原2和/或3似乎是狨猴感染所必需的，而在小鼠脑部感染中它们并非必需。含有凝集原1的疫苗（提取物或全细胞）可能足以通过小鼠保护试验，但可能无法使儿童产生免疫。即使用于筛选此类提取物，小鼠试验也不够充分。
