鼠还是人？哪种百日咳疫苗用于保护？
Mouse or man? Which are pertussis vaccines to protect?
作者信息
Preston N W, Stanbridge T N
出版信息
J Hyg (Lond). 1976 Apr;76(2):249-56. doi: 10.1017/s0022172400055145.
Abstract
Type 1 strains of Bordetella pertussis can infect mouse brain and have been recovered as type 1 organisms after death. When introduced into the naso-pharynx of the marmoset, they immediately acquired agglutinogen 2 or 3, and the resulting type 1,2 or 1,3 infection persisted for many weeks. As in the child, agglutinogens 2 and/or 3 appear to be essential for infection of the marmoset, whereas they are quite unnecessary in mouse brain. A vaccine (extract or whole cell) containing agglutinogen 1 may be sufficient to pass the mouse protection test but it may fail to immunize children. The mouse test is inadequate even for the screening of such extracts.
摘要
百日咳博德特氏菌1型菌株可感染小鼠脑部，并在小鼠死后作为1型菌株被分离出来。将其接种于狨猴的鼻咽部后，它们立即获得凝集原2或3，由此产生的1,2型或1,3型感染可持续数周。与儿童一样，凝集原2和/或3似乎是狨猴感染所必需的，而在小鼠脑部感染中它们并非必需。含有凝集原1的疫苗（提取物或全细胞）可能足以通过小鼠保护试验，但可能无法使儿童产生免疫。即使用于筛选此类提取物，小鼠试验也不够充分。
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本文引用的文献
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Mouse Protection Tests in the Study of Pertussis Vaccine: A Comparative Series Using the Intracerebral Route for Challenge.百日咳疫苗研究中的小鼠保护试验：采用脑内接种途径进行攻击的比较系列试验。
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Antigens of Bordetella pertussis V. Separation of Agglutinogen 1 and Mouse-Protective Antigen.百日咳博德特氏菌抗原 V. 凝集原 1 和鼠保护抗原的分离。
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The relation between agglutinin production by pertussis vaccines and their immunising potency in mice.百日咳疫苗的凝集素产生与其在小鼠中的免疫效力之间的关系。
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Some factors influencing the virulence for mice of Bordetella pertussis by the intracerebral route.一些通过脑内途径影响百日咳博德特氏菌对小鼠毒力的因素。
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Protective antigen of haemophilus pertussis.百日咳杆菌保护性抗原。
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Some observations made during experiments on mice inoculated with H. pertussis.在对感染百日咳杆菌的小鼠进行实验期间所做的一些观察。
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Potency tests for pertussis vaccines: doubtful value of intracerebral challenge test in mice.百日咳疫苗的效价检测：小鼠脑内攻击试验的可疑价值
J Pathol Bacteriol. 1966 Jan;91(1):173-9. doi: 10.1002/path.1700910121.
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Variation of serotype in strains of Bordetella pertussis.百日咳博德特氏菌菌株血清型的变异
J Hyg (Lond). 1974 Oct;73(2):305-10. doi: 10.1017/s0022172400024165.
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