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盐酸泰洛龙对几种动物病毒在组织培养中生长的影响。

The effect of tilorone hydrochloride on the growth of several animal viruses in tissue cultures.

作者信息

Katz E, Margalith E, Winer B

出版信息

J Gen Virol. 1976 Apr;31(1):125-9. doi: 10.1099/0022-1317-31-1-125.

DOI:10.1099/0022-1317-31-1-125
PMID:177724
Abstract

Tilorone hydrochloride, at a concentration of 10 mug/ml inhibits the growth of herpes simplex virus type 1 in BS-C-1 cells. The growth of vaccinia virus in BS-C-1 cells is partially inhibited; however, six viruses containing RNA, including four members of the togavirus group grown in chick fibroblasts, are not affected by the drug. The inhibition of the growth of herpes virus by tilorone hydrochloride is greater when the multiplicity of infection is lower than 1 p.f.u/cell and when the drug is added early in the course of infection.

摘要

浓度为10微克/毫升的盐酸替洛隆可抑制单纯疱疹病毒1型在BS-C-1细胞中的生长。痘苗病毒在BS-C-1细胞中的生长受到部分抑制;然而,六种含RNA的病毒,包括在鸡成纤维细胞中生长的披膜病毒科的四个成员,不受该药物影响。当感染复数低于1个蚀斑形成单位/细胞且在感染过程早期添加该药物时,盐酸替洛隆对疱疹病毒生长的抑制作用更强。

相似文献

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The effect of tilorone hydrochloride on the growth of several animal viruses in tissue cultures.盐酸泰洛龙对几种动物病毒在组织培养中生长的影响。
J Gen Virol. 1976 Apr;31(1):125-9. doi: 10.1099/0022-1317-31-1-125.
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Antiviral and Anticancer Activity of Cisplatin Derivatives of Tilorone.替洛隆顺铂衍生物的抗病毒和抗癌活性
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Antimicrob Agents Chemother. 2018 Jan 25;62(2). doi: 10.1128/AAC.01711-17. Print 2018 Feb.
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