Roner Michael R, Carraher Charles E, Dhanji Salima, Barot Girish
1Department of Biology, University of Texas at Arlington, Arlington, TX 76010 USA.
2Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431 USA.
J Inorg Organomet Polym Mater. 2008;18(3):374. doi: 10.1007/s10904-008-9219-7. Epub 2008 Jun 24.
Cisplatin derivatives containing tilorone and a tilorone derivative were synthesized and characterized employing IR analysis, mass spectrometry, elemental analysis, and chain length. The polymeric cisplatin derivatives prevent growth of four transformed cell lines, L929, 143, Vero, and BS-C-1 and effectively inhibit four viruses including the DNA viruses; herpes simplex-1, vaccinia, and Varicella zoster, and the RNA virus, reovirus in the micrograms/mL range. The tilorone polymers display activity against both transformed cells and DNA and RNA viruses at biologically important concentrations.
合成了含泰勒菌素和泰勒菌素衍生物的顺铂衍生物，并通过红外分析、质谱分析、元素分析和链长进行了表征。这些聚合顺铂衍生物可阻止四种转化细胞系（L929、143、Vero和BS-C-1）的生长，并能有效抑制四种病毒，包括DNA病毒单纯疱疹病毒-1、痘苗病毒和水痘带状疱疹病毒，以及RNA病毒呼肠孤病毒，其有效浓度在微克/毫升范围内。泰勒菌素聚合物在具有生物学意义的浓度下对转化细胞以及DNA和RNA病毒均具有活性。
