[烟草花叶病毒、泰洛龙和核酸钠的干扰素诱导及抗病毒活性]
[Interferonogenic and antiviral activity of the tobacco mosaic virus, tilorone and sodium nucleinate].
作者信息
Balezina T I, Fadeeva L L, Zemskov V M, Korneeva L E, Loĭdina G I
出版信息
Antibiotiki. 1976 Mar;21(3):250-4.
Production of endogenic interferon in animals in responce to administration of tobaco mozaic virus, tilorone and sodium nucleinate was shown. Dependence of interferon production on the type of the inductor and the route of its administration was studied. Absolute innocuiuty of the tobaco mozaic virus for monkeys (macaco-resus) and mice, as well as the absence of any side effects in humans treated with it perorally was shown. The tobaco mozaic virus, tilorone and sodium nucleinate used perorally in treatment of experimental infections of mice caused by the viruses of East and West encephalomyelitis, influenza and tick encephalitis had a pronounced protective effect.
已证实，动物在接种烟草花叶病毒、泰洛龙和核酸钠后会产生内源性干扰素。研究了干扰素产生与诱导剂类型及其给药途径的相关性。已证实烟草花叶病毒对猴子（猕猴）和小鼠绝对无害，并且口服该病毒的人体未出现任何副作用。口服烟草花叶病毒、泰洛龙和核酸钠用于治疗由东部和西部脑脊髓炎病毒、流感病毒和蜱传脑炎病毒引起的小鼠实验性感染时，具有显著的保护作用。
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