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[可乐定镇痛时降压作用的神经生理机制]

[Neurophysiological mechanisms of the antihypertensive effect of clopheline in pain].

作者信息

Ignatov Iu D, Bogdanov E G, Zaĭtsev A A, Khar'kovskiĭ A O

出版信息

Biull Eksp Biol Med. 1991 Dec;112(12):593-5.

PMID:1777618
Abstract

In experiments on conscious and unanesthetized cats it was shown that clopheline in analgesic doses do not change the pain baroreflex blood pressure regulation and mild brain antinociceptive sympathoactivating influences. The clopheline antihypertensive effect was due to nonopiate direct sympathoinhibitory effect realized by suprasegmental level of vasomotor regulation.

摘要

在对清醒且未麻醉的猫进行的实验中发现,镇痛剂量的氯菲宁不会改变痛觉压力反射性血压调节以及轻微的脑内抗伤害性感受交感激活作用。氯菲宁的降压作用归因于由血管运动调节的节段上水平实现的非阿片类直接交感抑制作用。

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1
[Neurophysiological mechanisms of the antihypertensive effect of clopheline in pain].[可乐定镇痛时降压作用的神经生理机制]
Biull Eksp Biol Med. 1991 Dec;112(12):593-5.
2
[Analgesic effect of clopheline].[氯非那明的镇痛作用]
Biull Eksp Biol Med. 1981 Dec;92(12):690-2.
3
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[Role of alpha-sympathomimetic agents in the central nervous system. Study of the central effects of adrenergic drugs by injection into the vertebral artery].[α-拟交感神经药在中枢神经系统中的作用。通过椎动脉注射研究肾上腺素能药物的中枢效应]
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[The analgesic action of clofelin administered via the cerebral ventricles and the theca medullaris spinalis].[通过脑室及脊髓蛛网膜下腔给药的氯非林的镇痛作用]
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