[Analgesic effect of clopheline].

Clophelin significantly decreases the intensity of behavioral and hemodynamic manifestations of nociceptive reactions and inhibits spontaneous behavior only in doses exerting a powerful hypotensive action in normotensive unrestrained cats (0.02-0.03 mg/kg) and rats (2-4 mg/kg). A similar correlation between the inhibition of nociceptive reactions and hypotension was revealed in experiments with papaverine (5-8 mg/kg). Naloxone averts the clopheline-induced hypotension and inhibition of the emotional and behavioral manifestations rather than recovers the hemodynamic nociceptive reactions. It is assumed that clophelin has no genuine morphine-like analgetic action.