Zaĭtsev A A, Ignatov Iu D, Dmitriev A V
Biull Eksp Biol Med. 1981 Dec;92(12):690-2.
Clophelin significantly decreases the intensity of behavioral and hemodynamic manifestations of nociceptive reactions and inhibits spontaneous behavior only in doses exerting a powerful hypotensive action in normotensive unrestrained cats (0.02-0.03 mg/kg) and rats (2-4 mg/kg). A similar correlation between the inhibition of nociceptive reactions and hypotension was revealed in experiments with papaverine (5-8 mg/kg). Naloxone averts the clopheline-induced hypotension and inhibition of the emotional and behavioral manifestations rather than recovers the hemodynamic nociceptive reactions. It is assumed that clophelin has no genuine morphine-like analgetic action.
氯苯乙胍仅在对正常血压且未受束缚的猫（0.02 - 0.03毫克/千克）和大鼠（2 - 4毫克/千克）产生强大降压作用的剂量下，才会显著降低伤害性反应的行为和血流动力学表现的强度，并抑制自发行为。在使用罂粟碱（5 - 8毫克/千克）的实验中也发现了伤害性反应抑制与低血压之间的类似相关性。纳洛酮可避免氯苯乙胍引起的低血压以及对情绪和行为表现的抑制，但无法恢复血流动力学伤害性反应。据推测，氯苯乙胍没有真正的类吗啡镇痛作用。
