Deftos L J, McMillan P J, Sartiano G P, Abuid J, Robinson A G
Metabolism. 1976 May;25(5):543-50. doi: 10.1016/0026-0495(76)90008-1.
Two patients with cancer were evaluated in whom there was evidence for the simultaneous ectopic production of parathyroid hormone (PTH) and calcitonin (CT). One patient had a gastric carcinoid and the other had a pancreatic islet cell carcinoma. Abnormal concentrations of parathyroid hormone and calcitonin were demonstrated by radioimmunoassay in the peripheral blood of each patient and in the gastric tumor. In the pancreatic tumor, immunohistologic studies also demonstrated the presence of CT and PTH and suggested that each hormone was produced by different cells of the tumor. Plasma concentrations of the hormones responded to functional tests of secretion and to tumor chemotherapy. These studies demonstrate the simultaneous ectopic production of the two physiologically antagonistic hormones, PTH and CT, and confirm their value as diagnostic markers for several types of malignancies.
对两名癌症患者进行了评估，发现他们有甲状旁腺激素（PTH）和降钙素（CT）同时异位分泌的证据。一名患者患有胃类癌，另一名患者患有胰岛细胞瘤。通过放射免疫分析在每名患者的外周血和胃肿瘤中检测到甲状旁腺激素和降钙素浓度异常。在胰腺肿瘤中，免疫组织学研究也证实了CT和PTH的存在，并表明每种激素由肿瘤的不同细胞产生。激素的血浆浓度对分泌功能试验和肿瘤化疗有反应。这些研究证明了生理上具有拮抗作用的两种激素PTH和CT可同时异位分泌，并证实了它们作为几种恶性肿瘤诊断标志物的价值。
