Rebuffé-Scrive M, Mårin P, Björntorp P
Department of Medicine 1, Sahlgren's Hospital, University of Göteborg, Sweden.
Int J Obes. 1991 Nov;15(11):791-5.
Recent studies in men have shown that abdominal fat increases with age and decreasing testosterone concentrations. Furthermore, in cell culture, testosterone expresses an increased lipolytic potential and depresses lipoprotein lipase activity (LPL) in adipose cells. These metabolic characteristics are found in abdominal adipose tissue in young men. In order to see whether abdominal fat masses in moderately obese middle-aged men might be diminished by testosterone, this hormone was given either as a single injection (500 mg) or in moderate doses (40 mg X 4) for 6 weeks in an oral preparation, bypassing the liver. When measured 1 week after the single dose, abdominal LPL tended to decrease. After 6 weeks a dramatic decrease of abdominal LPL was found, as well as an increase in the lipolytic responsiveness to norepinephrine, both changes confined solely to the abdominal, and not femoral adipose tissue regions. The waist/hip circumference decreased in 9 out of the 11 examined men. No untoward effects were seen in behavioural variables, blood pressure, triglyceride or cholesterol values, and liver function tests. These preliminary results suggest that administration of testosterone in moderate doses to middle-aged men lead to adaptations of the metabolism of adipose tissue expected to be followed by a diminution of this mass.
近期针对男性的研究表明，腹部脂肪会随着年龄增长以及睾酮浓度降低而增加。此外，在细胞培养中，睾酮表现出增强的脂肪分解潜能，并抑制脂肪细胞中的脂蛋白脂肪酶活性（LPL）。这些代谢特征在年轻男性的腹部脂肪组织中也有发现。为了探究睾酮是否能减少中度肥胖中年男性的腹部脂肪量，该激素以单次注射（500毫克）或口服制剂的中等剂量（40毫克×4）给药6周，绕过肝脏。单次给药1周后测量发现，腹部LPL有下降趋势。6周后，发现腹部LPL显著下降，同时对去甲肾上腺素的脂肪分解反应性增加，这两种变化仅局限于腹部，而非股部脂肪组织区域。在接受检查的11名男性中，有9人的腰臀围减小。在行为变量、血压、甘油三酯或胆固醇值以及肝功能测试方面未观察到不良影响。这些初步结果表明，对中年男性给予中等剂量的睾酮会导致脂肪组织代谢发生适应性变化，预计随后脂肪量会减少。
