Rosenberg L, Armstrong B, Jick H
N Engl J Med. 1976 Jun 3;294(23):1256-9. doi: 10.1056/NEJM197606032942302.
Data obtained from two multipurpose surveys of hospitalized patients were examined to determine the risk of nonfatal acute myocardial infarction in post-menopausal women 40 to 75 years of age in relation to use of estrogen-containing drugs. Eight (2.4 per cent) of 336 myocardial infarction patients and 330 (4.9 per cent) of 6730 reference patients were regular estrogen users (crude rate ratio, 0.47) at the time of hospitalization. After control for confounding variables -- among them, age, past history of myocardial in farction, angina, diabetes, and hypertension (alone or in combination) and cigarette smoking -- the summary point estimate of rate ratio was 0.97 with 95 per cent confidence limits of 0.48 and 1.95. Thus, there was no evidence of a statistically significant association between current regular use of estrogens and nonfatal acute myocardial infarction.
对两项针对住院患者的多用途调查所获数据进行了分析，以确定40至75岁绝经后女性使用含雌激素药物与非致命性急性心肌梗死风险之间的关系。336例心肌梗死患者中有8例（2.4%）、6730例对照患者中有330例（4.9%）在住院时为常规雌激素使用者（粗率比为0.47）。在对年龄、既往心肌梗死病史、心绞痛、糖尿病、高血压（单独或合并存在）以及吸烟等混杂变量进行控制后，率比的汇总点估计值为0.97，95%置信区间为0.48至1.95。因此，目前尚无证据表明常规使用雌激素与非致命性急性心肌梗死之间存在统计学上的显著关联。
