Jick H, Dinan B, Rothman K J
JAMA. 1978 Apr 3;239(14):1407-9.
We obtained information on 107 women younger than 46 years discharged from a hospital with a diagnosis of acute myocardial infarction. In the series there were 17 women aged 39 to 45 years who were otherwise apparently healthy and had had a natural menopause, hysterectomy, or tubal ligation or whose spouse had had a vasectomy. Among them, nine (53%) were taking noncontraceptive estrogens just prior to admission. Among 34 control women, four (12%) were taking estrogens. The relative risk estimate, comparing estrogen users with nonusers, is 7.5, with 90% confidence limits of 2.4 and 24. All but one of the 17 ml subjects were cigarette smokers. While this illness is rare in most healthy young women, the risk in women older than about 38 years who both smoke and take estrogens appears to be substantial.
我们获取了107名46岁以下因急性心肌梗死诊断而从医院出院的女性的信息。在这个系列中，有17名年龄在39至45岁之间的女性，她们在其他方面显然健康，经历过自然绝经、子宫切除术或输卵管结扎术，或者其配偶接受过输精管切除术。其中，9名（53%）在入院前正在服用非避孕雌激素。在34名对照女性中，4名（12%）正在服用雌激素。将雌激素使用者与非使用者进行比较，相对风险估计值为7.5，90%置信区间为2.4至24。17名研究对象中除一人外均为吸烟者。虽然这种疾病在大多数健康年轻女性中很少见，但对于年龄超过约38岁且既吸烟又服用雌激素的女性来说，风险似乎很大。
