两个不同时间段南欧人群中痴呆症的患病率：ZARADEMP项目
Prevalence of dementia in a southern European population in two different time periods: the ZARADEMP Project.
作者信息
Lobo A, Saz P, Marcos G, Dia J L, De-la-Camara C, Ventura T, Montañes J A, Lobo-Escolar A, Aznar S
机构信息
Department of Psychiatry, Hospital Clínico Universitario, Zaragoza, Spain.
出版信息
Acta Psychiatr Scand. 2007 Oct;116(4):299-307. doi: 10.1111/j.1600-0447.2007.01006.x.
OBJECTIVE
To compare the prevalence of dementia in two different time periods and two different studies.
METHOD
Representative, random samples of the elderly (>65 years) in the Zaragoza Study or ZARADEMP-0 (n = 1080) completed the previous decade, and now in Wave I of the ZARADEMP Project or ZARADEMP-I (n = 3715) were interviewed. Standardized measures included the Geriatric Mental State and the History and Aetiology schedule. Cases of dementia were diagnosed according to DSM-IV criteria.
RESULTS
Adjusted, global prevalence of dementia has not varied significantly: it was 5.2% (95% CI = 3.9-6.6) in ZARADEMP-0 and 3.9% (95% CI = 3.3-4.5) in ZARADEMP-I (prevalence ratio = 0.75; 95% CI = 0.56-1.02). However, the prevalence in ZARADEMP-I was significantly lower among men, particularly in all age groups between 70 and 84 years.
CONCLUSION
Stability of the global prevalence of dementia in the elderly population has been documented. However, the decreased prevalence found in elderly men stimulated environmental hypotheses.
目的
比较两个不同时间段以及两项不同研究中痴呆症的患病率。
方法
萨拉戈萨研究或ZARADEMP - 0（n = 1080）中具有代表性的65岁以上老年人随机样本完成了上一个十年的研究，现在对ZARADEMP项目第一阶段或ZARADEMP - I（n = 3715）中的老年人进行了访谈。标准化测量包括老年精神状态以及病史和病因学调查表。根据《精神疾病诊断与统计手册》第四版标准诊断痴呆症病例。
结果
经调整后的痴呆症总体患病率无显著变化：在ZARADEMP - 0中为5.2%（95%置信区间 = 3.9 - 6.6），在ZARADEMP - I中为3.9%（95%置信区间 = 3.3 - 4.5）（患病率比 = 0.75；95%置信区间 = 0.56 - 1.02）。然而，ZARADEMP - I中男性的患病率显著较低，尤其是在70至84岁的所有年龄组中。
结论
已证明老年人群中痴呆症总体患病率具有稳定性。然而，老年男性中患病率的下降引发了对环境因素的假设。
Zotero 插件