系统生物学中的成像技术。

Imaging in systems biology.

作者信息

Megason Sean G, Fraser Scott E

机构信息

Beckman Institute, Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.

出版信息

Cell. 2007 Sep 7;130(5):784-95. doi: 10.1016/j.cell.2007.08.031.

DOI:10.1016/j.cell.2007.08.031

PMID:17803903

Abstract

Most systems biology approaches involve determining the structure of biological circuits using genomewide "-omic" analyses. Yet imaging offers the unique advantage of watching biological circuits function over time at single-cell resolution in the intact animal. Here, we discuss the power of integrating imaging tools with more conventional -omic approaches to analyze the biological circuits of microorganisms, plants, and animals.

摘要

大多数系统生物学方法涉及通过全基因组“组学”分析来确定生物回路的结构。然而，成像具有独特的优势，能够在完整动物体内以单细胞分辨率观察生物回路随时间的功能。在此，我们讨论将成像工具与更传统的组学方法相结合以分析微生物、植物和动物生物回路的作用。