Boyd J L, Cruickshank C A, Kenn C W, Madeley P, Mindham R H, Oswald A G, Smith R J, Spokes E G
Department of Psychiatry, University of Leeds.
Psychol Med. 1991 Nov;21(4):911-21. doi: 10.1017/s0033291700029901.
The performance of 47 patients with Parkinson's disease on a battery of tests of cognition, motor function, disability and mood was compared with the performance of 47 healthy control subjects who were matched to the patients on the basis of age, sex and pre-morbid IQ. An increased prevalence of impairment over a range of cognitive functions was observed in the Parkinson's disease patients as compared with their matched controls. The differences between the Parkinson's disease patients and controls could not be accounted for by factors such as depressed mood, effects of medication or motor impairment. Our findings are discussed in relation to the methodology of previous studies in this area and to the need for a comprehensive clinico-pathological longitudinal study.
将47例帕金森病患者在一系列认知、运动功能、残疾和情绪测试中的表现，与47名在年龄、性别和病前智商方面与患者相匹配的健康对照者的表现进行了比较。与匹配的对照组相比，帕金森病患者在一系列认知功能方面的损伤患病率有所增加。帕金森病患者与对照组之间的差异不能用情绪低落、药物作用或运动障碍等因素来解释。我们结合该领域以往研究的方法以及全面的临床病理纵向研究的必要性，对我们的研究结果进行了讨论。
