Tunca Yasar Meric, Aydin Cumhur, Ozen Tuncer, Seyrek Melik, Ulusoy Hasan Basri, Yildiz Oguzhan
Department of Endodontics, Center of Dental Sciences, Gulhane School of Medicine, Ankara, Turkey.
J Endod. 2007 Jul;33(7):823-6. doi: 10.1016/j.joen.2007.03.007. Epub 2007 Apr 17.
Mineral trioxide aggregate (MTA) is being advocated for vital pulp therapy. In the case of direct pulp capping, hemorrhage control is an important step on success, but little is known about the effect of MTA on pulpal bleeding. In addition, there has been a lack of information on the effect of MTA on smooth muscle contraction, such as can occur in the blood vessels of dental pulp. The present study assessed the vascular effects of MTA, using the rat aortic ring preparations as a tissue model. MTA (100-500 mg) induced dose-dependent contraction in rat thoracic aorta. The contractile effect of MTA was blocked by calcium channel blocker nifedipine (1 muM). These data suggest that the vasoconstrictor property of MTA is related to calcium influx and it may allow proper control of hemorrhage which is critical for the success of any pulp-capping treatment.
三氧化矿物凝聚体（MTA）正被提倡用于牙髓活力治疗。在直接盖髓的情况下，控制出血是成功的重要步骤，但关于MTA对牙髓出血的影响知之甚少。此外，关于MTA对平滑肌收缩（如牙髓血管中可能发生的收缩）的影响也缺乏相关信息。本研究以大鼠主动脉环标本作为组织模型，评估了MTA的血管效应。MTA（100 - 500毫克）在大鼠胸主动脉中诱导剂量依赖性收缩。MTA的收缩效应被钙通道阻滞剂硝苯地平（1微摩尔）阻断。这些数据表明，MTA的血管收缩特性与钙内流有关，并且它可能有助于对出血进行适当控制，这对于任何盖髓治疗的成功至关重要。
