Takaya M, Ichikawa Y, Shimizu H, Uchiyama M, Moriuchi J, Arimori S
Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan.
Tokai J Exp Clin Med. 1991 Jul;16(2):83-8.
We analyzed 117 histories of pregnancy obtained from 40 female patients with Sjögren's syndrome (SS) including 13 patients with primary SS and 27 patients with secondary SS. The frequency of spontaneous abortions did not differ in the 40 patients and those with primary SS compared with 129 healthy women. However, both spontaneous abortions and premature deliveries were significantly more frequent in the SS patients with systemic lupus erythematosus (SLE). Anti-SS-A and anti-SS-B antibodies were not associated with the outcomes of pregnancy although spontaneous abortions were more frequent in secondary SS patients with false positive serological tests for syphilis, anti-erythrocyte antibodies, thrombocytopenia or prolonged activated partial thromboplastin time. Neither congenital anomalies nor connective tissue disease was found in the 77 neonates of the patients. We concluded that SS does not influence the outcome of pregnancy except in patients with SLE or those with serological and hematological abnormalities related to lupus anticoagulants or antiphospholipid antibodies.
我们分析了40例干燥综合征（SS）女性患者的117份妊娠史，其中包括13例原发性SS患者和27例继发性SS患者。与129名健康女性相比，这40例患者及原发性SS患者的自然流产发生率并无差异。然而，患有系统性红斑狼疮（SLE）的SS患者中，自然流产和早产的发生率均显著更高。抗SS - A和抗SS - B抗体与妊娠结局无关，尽管在梅毒血清学检测假阳性、抗红细胞抗体、血小板减少或活化部分凝血活酶时间延长的继发性SS患者中自然流产更为常见。在这些患者的77名新生儿中，未发现先天性异常或结缔组织病。我们得出结论，除了患有SLE的患者或那些有与狼疮抗凝物或抗磷脂抗体相关的血清学和血液学异常的患者外，SS不会影响妊娠结局。
