Medhat A M, el-Din Abdelwahab K S, el Aaser A A, al-Nagdy S A, el-Dardiri Z Z
Department of Biochemistry, Faculty of Science, Ain Shams University, Cairo, Egypt.
Tumori. 1991 Oct 31;77(5):372-8. doi: 10.1177/030089169107700502.
Soybean and/or sodium ascorbate have been demonstrated to have protective effects against carcinogenicity of the nitrosamine precursors dibutylamine and sodium nitrite in rats. Some immunological aspects of the cellular and humoral compartments of the immune system were investigated in this experimental model. The parameters chosen for the study were the lymphocyte transformation test, migration inhibition test, the demonstration of Fc and Fc plus complement receptors on the lymphocyte surface (EA and EAC rosette-forming test), and the determination of total serum proteins and their fractions. The results indicated that dibutylnitrosamine can be formed in vivo from its precursors dibutylamine and sodium nitrite, and that it affects the immune system of rats which showed an immunosuppressed state present as depressed cellular and humoral immunity. The protective role of soybean and/or ascorbate against carcinogenicity of dibutylamine and sodium nitrite was demonstrated by the absence of tumor formation. These agents were found to be capable of increasing the defense mechanism of rats by enhancing both cellular and humoral immunity in the presence of the carcinogenic nitrosamine precursors dibutylamine and sodium nitrite.
大豆和/或抗坏血酸钠已被证明对大鼠体内亚硝胺前体二丁胺和亚硝酸钠的致癌性具有保护作用。在这个实验模型中，对免疫系统的细胞和体液部分的一些免疫学方面进行了研究。本研究选择的参数包括淋巴细胞转化试验、迁移抑制试验、淋巴细胞表面Fc和Fc加补体受体的检测（EA和EAC花环形成试验）以及血清总蛋白及其组分的测定。结果表明，二丁基亚硝胺可由其前体二丁胺和亚硝酸钠在体内形成，并且它会影响大鼠的免疫系统，表现为细胞免疫和体液免疫受到抑制的免疫抑制状态。大豆和/或抗坏血酸对二丁胺和亚硝酸钠致癌性的保护作用通过无肿瘤形成得到证明。发现这些物质能够在致癌性亚硝胺前体二丁胺和亚硝酸钠存在的情况下，通过增强细胞免疫和体液免疫来提高大鼠的防御机制。
