Schastnyĭ S A, Samsygin S A, Kostomarova G A, Varlamov E V, Vlasenko V V, Dolgina E N, Ekk N D
Vestn Akad Med Nauk SSSR. 1991(7):43-6.
A study was made of the clinical efficacy and immune status in 40 children with chronic osteomyelitis of long tubular bones. Of these, 13 patients received antibiotics endolymphatically and 27 patients were given conventional antibiotic therapy (intramuscularly, intravenously). In view of the predominance of the staphylococcal flora, endolymphatic therapy included the use of gentamycin and lincomycin, the treatment course lasted up to 10 days. Endolymphatic antibacterial therapy has been demonstrated to produce a beneficial clinical effect there was a decrease in fever duration, the amount of postoperative complications, and the duration of inpatient treatment. After endolymphatic therapy the patients' blood manifested a more remarkable, as compared to the control group, rise of the absolute count of T lymphocytes, "active" population of T lymphocytes, together with an increase of the functional activity of lymphocytes in blast transformation, and a reduction, to an equal degree, of the neutrophil and monocyte counts, attesting to a decline of antigenic load of phagocytes. In patients who received antibiotics endolymphatically, the general blood analysis showed a decrease of neutrophilia and marked lymphocytosis. All this mirrored the intensity of immunity activation.
对40例长管状骨慢性骨髓炎患儿的临床疗效和免疫状态进行了研究。其中13例患者接受了内淋巴途径抗生素治疗，27例患者接受了传统抗生素治疗（肌肉注射、静脉注射）。鉴于葡萄球菌菌群占优势，内淋巴治疗使用庆大霉素和林可霉素，疗程长达10天。内淋巴抗菌治疗已被证明可产生有益的临床效果，发热持续时间、术后并发症数量和住院治疗时间均有所减少。内淋巴治疗后，与对照组相比，患者血液中T淋巴细胞绝对计数、“活跃”T淋巴细胞群体显著升高，淋巴细胞在 blast 转化中的功能活性增加，中性粒细胞和单核细胞计数同等程度降低，证明吞噬细胞抗原负荷下降。接受内淋巴途径抗生素治疗的患者，血常规显示中性粒细胞增多症减少，淋巴细胞明显增多。所有这些都反映了免疫激活的强度。
