Samsygin S A, Schastnyĭ S A, Vlasenko V V, Dolgina E N, Ekk N D
Vestn Akad Med Nauk SSSR. 1991(12):50-4.
Children suffering from chronic osteomyelitis of long tubular bones were compared for the action of the immunomodulating drug tactivin injected subcutaneously and endolymphatically. The study was carried out in 57 patients staying in hospital. The patients were distributed into the following groups: 18 patients entered a group where tactivin was injected subcutaneously, 9 patients made up a group where the drug was administered endolymphatically, and a reference group included 30 patients treated by conventional methods. On admission the patients demonstrated secondary immunodeficiency characterized by the lowering of the absolute and relative T lymphocyte count, a decrease of functional activity in blast transformation of lymphocytes, and dysimmunoglobulinemia. The use of immunomodulation with tactivin whatever the route of administration promoted a more uneventful course of the postoperative period, a decrease of suppurations of the postoperative wounds, reduction of the patient's hospital stay, a decrease in the dose of antibacterial drugs required for continuous treatment, and enhancement of the efficacy of antibacterial therapy. The use of tactivin endolymphatically brings about rapid normalization of the count of T, T active and B lymphocytes, an increase of the indicated parameters to the lower limit of normal on subcutaneous injection. As for the reference group, these parameters continue a progressive lowering.
对患有长管状骨慢性骨髓炎的儿童进行了比较，观察皮下注射和经内淋巴注射免疫调节药物tactivin的作用。该研究在57名住院患者中进行。患者被分为以下几组：18名患者进入皮下注射tactivin的组，9名患者组成经内淋巴给药的组，对照组包括30名采用传统方法治疗的患者。入院时，患者表现出继发性免疫缺陷，其特征为绝对和相对T淋巴细胞计数降低、淋巴细胞母细胞转化功能活性降低以及免疫球蛋白异常血症。无论采用何种给药途径，使用tactivin进行免疫调节均能使术后病程更平稳，术后伤口化脓减少，患者住院时间缩短，持续治疗所需抗菌药物剂量减少，并提高抗菌治疗效果。经内淋巴注射tactivin可使T、T活性和B淋巴细胞计数迅速恢复正常，皮下注射时上述参数增加至正常下限。至于对照组，这些参数则持续逐渐降低。
