Artacho-Pérula E, Roldán-Villalobos R, Vaamonde-Lemos R
Department of Morphological Sciences (Section of Histology), School of Medicine, University of Córdoba, Spain.
Acta Anat (Basel). 1991;142(1):70-6. doi: 10.1159/000147163.
The present study examines the influence of ischemia on the muscle fibers and capillarization in rats. Muscle ischemia was achieved by a pneumatic tourniquet at a pressure of 300 mm Hg for 2, 4 and 6 h (groups I, II and III, respectively) to the right hindlimb above the knee. Numerous regenerative fibers were seen at 4 and, especially, 8 and 12 days after ischemia in groups II and III. The quantitative data revealed a significant decrease in the size of muscle fibers (regenerative fibers) in ischemic skeletal muscle, with a concomitant increase in fiber density. The capillary to fiber ratio shows a decrease at 4, 8 and 12 days after ischemia in the three experimental groups: in group I because of a decrease in capillary density; in groups II and III because of an increase in fiber density with respect to capillary density.
本研究探讨了缺血对大鼠肌肉纤维和毛细血管形成的影响。通过在右后肢膝盖上方使用压力为300毫米汞柱的气动止血带，分别对大鼠右后肢进行2小时、4小时和6小时的缺血处理（分别为I组、II组和III组）。在II组和III组中，缺血后4天，尤其是8天和12天可见大量再生纤维。定量数据显示，缺血骨骼肌中肌肉纤维（再生纤维）大小显著减小，同时纤维密度增加。在三个实验组中，缺血后4天、8天和12天，毛细血管与纤维的比例均降低：I组是由于毛细血管密度降低；II组和III组是由于纤维密度相对于毛细血管密度增加。
