Thind K S, Karmali S, House R A
Health and Safety Division, Ontario Hydro, Pickering, Canada.
Am Ind Hyg Assoc J. 1991 Dec;52(12):547-52. doi: 10.1080/15298669191365180.
Occupational exposure to pentachlorophenol (PCP) for a crew of electrical utility linemen was monitored over a 6-month period by using total PCP in urine per gram of creatinine as a biological monitoring parameter. Urine samples were collected from three groups: A, B, and control, at a 4-week frequency during 1989. Group A was required to use new gloves after each 4-week work period; Group B changed gloves on a need basis as per normal operating procedure. The control group consisted of members of the administrative office staff who were not occupationally exposed. The used gloves returned by Group A were monitored for contamination. On the basis of analysis of the collected data the following conclusions were noted. (1) The linemen experienced a seasonal exposure pattern with exposures peaking in July and August. This seasonal effect was also observed with glove contamination data. (2) The glove contamination levels were significantly associated with urine PCP concentrations when both these variables were expressed as geometric means for the individuals in Group A. Inclusion of work experience as an additional variable enhances this association. Less experienced linemen tended to perform more activities with higher current exposure and had higher urine and glove PCP measurements and higher correlations between these variables than more experienced linemen. (3) Over the study period, the difference in long-term exposures of Group A and Group B linemen was not statistically significant. (4) The long-term individual exposures, calculated as the geometric mean of each individual's sequential sample readings, were all below the biological monitoring guideline value of 1000 micrograms PCP/g creatinine.
在6个月的时间里，以每克肌酐中五氯苯酚（PCP）的总量作为生物监测参数，对一组电力公司线路工人的职业性PCP暴露情况进行了监测。1989年期间，每4周从A组、B组和对照组采集尿液样本。A组被要求在每4周的工作期后使用新手套；B组按照正常操作程序根据需要更换手套。对照组由未接触职业暴露的行政办公室工作人员组成。对A组归还的用过的手套进行了污染监测。根据对收集数据的分析，得出以下结论：（1）线路工人呈现出季节性暴露模式，7月和8月暴露量达到峰值。手套污染数据也观察到了这种季节性影响。（2）当将这两个变量表示为A组个体的几何均值时，手套污染水平与尿液PCP浓度显著相关。将工作经验作为一个额外变量纳入会增强这种关联。经验不足的线路工人往往进行更多当前暴露量较高的活动，其尿液和手套中的PCP测量值更高，并且这些变量之间的相关性比经验丰富的线路工人更高。（3）在研究期间，A组和B组线路工人的长期暴露差异无统计学意义。（4）以每个个体连续样本读数的几何均值计算的长期个体暴露量均低于1000微克PCP/克肌酐的生物监测指导值。
