Begley J, Reichert E L, Rashad M N, Klemmer H W
Clin Toxicol. 1977;11(1):97-106. doi: 10.3109/15563657708989823.
Data are presented and renal function tests and Pcp measurements on consecutive blood and urine samples collected from 18 workers at a wood treatment plant before, during, and after a 20-day vacation. Pcp concentrations in blood averaging 5.1 ppm before vacation fell to 2.2 ppm during vacation but with a temporary rise early in this nonexposure period, suggesting a body tissues store of Pcp which was mobilized in response to a negative Pcp balance. Urine Pcp concentrations showed similar but less marked variations. Creatinine clearance and phosphorus reabsorption values were depressed before vacation but showed significant improvement during vacation, suggesting that Pcp exposure reduced both glomerular filtration rate and tubular function, with recovery following a nonexposure period.
本文呈现了对一家木材处理厂的18名工人在为期20天的假期前、假期中和假期后连续采集的血液和尿液样本进行的肾功能测试及五氯苯酚（Pcp）测量结果。假期前血液中Pcp浓度平均为5.1 ppm，假期期间降至2.2 ppm，但在这个无暴露期开始时出现了短暂上升，这表明身体组织中储存有Pcp，它会因Pcp负平衡而被调动。尿液中Pcp浓度显示出类似但不太明显的变化。肌酐清除率和磷重吸收值在假期前降低，但在假期期间有显著改善，这表明Pcp暴露降低了肾小球滤过率和肾小管功能，在无暴露期后得以恢复。
