Weber K T, Brilla C G, Janicki J S, Reddy H K, Campbell S E
Division of Cardiology, University of Missouri, Columbia.
Basic Res Cardiol. 1991;86 Suppl 3:25-31. doi: 10.1007/978-3-662-30769-4_3.
The myocardium contains myocyte and non-myocyte cells. A disproportionate growth of the nonmyocyte cell population can alter myocardial structure and lead to pathologic hypertrophy. Myocardial fibrosis, the result of cardiac fibroblast growth or abnormal accumulation of fibrillar collagen within the interstitial space, can adversely influence myocardial stiffness and ultimately ventricular function. We have examined the relative importance of ventricular systolic and arterial pressures and the effector hormones of the renin-angiotensin--aldosterone system in mediating this reactive fibrous tissue response in the hypertensive left and normotensive right ventricles in various experimental models of arterial hypertension. To date, our findings implicate arterial hypertension, together with an elevation in plasma aldosterone, as being contributory to the fibrosis in renovascular hypertension that creates tissue heterogeneity in either ventricle and impaired diastolic function. The endocrine properties of aldosterone in this nonclassical mineralocorticoid target tissue, the myocardium, requires further investigation.
心肌包含心肌细胞和非心肌细胞。非心肌细胞群体的过度生长会改变心肌结构并导致病理性肥大。心肌纤维化是心脏成纤维细胞生长或间质空间内纤维状胶原异常积聚的结果，会对心肌僵硬度产生不利影响，并最终影响心室功能。我们在各种动脉高血压实验模型中，研究了心室收缩压和动脉压以及肾素-血管紧张素-醛固酮系统的效应激素在介导高血压左心室和正常血压右心室这种反应性纤维组织反应中的相对重要性。迄今为止，我们的研究结果表明，动脉高血压以及血浆醛固酮升高是导致肾血管性高血压中纤维化的原因，这种纤维化在任一心室中造成组织异质性并损害舒张功能。醛固酮在这种非经典盐皮质激素靶组织（心肌）中的内分泌特性需要进一步研究。
