臭氧对苯并[a]芘的“大气”环氧化作用：代谢物苯并[a]芘-4,5-氧化物的形成。
"Atmospheric" Epoxidation of Benzo[a]pyrene by Ozone: Formation of the Metabolite Benzo[a]pyrene-4,5-Oxide.
出版信息
Science. 1980 Dec 19;210(4476):1347-9. doi: 10.1126/science.210.4476.1347.
Abstract
Benzo[a]pyrene deposited on a glass fiber filter reacts rapidly in the dark or light with ambient levels of ozone to yield a mixture of products that display strong direct mutagenicity in the Ames assay. The major stable contributor to this activity has been identified as benzo[a]pyrene-4,5-oxide, a DNA-binding metabolite in biological systems, known to be a strong direct mutagen with Salmonella typhimurium strain TA98.
摘要
苯并[a]芘沉积在玻璃纤维滤纸上，在黑暗或光照条件下与环境水平的臭氧迅速反应，生成显示出在艾姆斯试验中具有强烈直接致突变性的混合产物。这种活性的主要稳定贡献物已被确定为苯并[a]芘-4,5-氧化物，它是生物体系中与 DNA 结合的代谢物，已知是具有强直接致突变性的物质，可使鼠伤寒沙门氏菌 TA98 发生突变。
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