钒酸盐可激活戊糖磷酸途径和糖酵解，并提高泌乳期大鼠乳腺切片中果糖2,6 -二磷酸的浓度。
Vanadate activates pentose phosphate pathway and glycolysis, and raises fructose 2,6-bisphosphate concentration in slices of lactating rat mammary gland.
作者信息
Sochor M, Kunjara S, Sumathy K, el Hassan T, Greenbaum A L
机构信息
Department of Biochemistry, University College and Middlesex School of Medicine, London.
出版信息
Biochem Int. 1991 Aug;24(6):1111-8.
In mammary gland slices from lactating rats, vanadate increased the rate of glucose oxidation via the pentose phosphate pathway by 36% and raised the glucose flux via glycolysis by 47%. Furthermore, vanadate increased the fructose 2,6-bisphosphate (Fru-2,6-P2) level by 33%. The effect of vanadate on glucose oxidation was compared to the effect of insulin. The present data indicate that 0.5mM vanadate has an effect on glucose utilization similar to that of insulin but does not reach the same level.
在泌乳大鼠的乳腺切片中，钒酸盐使通过磷酸戊糖途径的葡萄糖氧化速率提高了36%，并使通过糖酵解的葡萄糖通量提高了47%。此外，钒酸盐使果糖2,6-二磷酸（Fru-2,6-P2）水平提高了33%。将钒酸盐对葡萄糖氧化的作用与胰岛素的作用进行了比较。目前的数据表明，0.5mM钒酸盐对葡萄糖利用的作用与胰岛素相似，但未达到相同水平。
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