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钒酸盐可激活戊糖磷酸途径和糖酵解,并提高泌乳期大鼠乳腺切片中果糖2,6 -二磷酸的浓度。

Vanadate activates pentose phosphate pathway and glycolysis, and raises fructose 2,6-bisphosphate concentration in slices of lactating rat mammary gland.

作者信息

Sochor M, Kunjara S, Sumathy K, el Hassan T, Greenbaum A L

机构信息

Department of Biochemistry, University College and Middlesex School of Medicine, London.

出版信息

Biochem Int. 1991 Aug;24(6):1111-8.

PMID:1781790
Abstract

In mammary gland slices from lactating rats, vanadate increased the rate of glucose oxidation via the pentose phosphate pathway by 36% and raised the glucose flux via glycolysis by 47%. Furthermore, vanadate increased the fructose 2,6-bisphosphate (Fru-2,6-P2) level by 33%. The effect of vanadate on glucose oxidation was compared to the effect of insulin. The present data indicate that 0.5mM vanadate has an effect on glucose utilization similar to that of insulin but does not reach the same level.

摘要

在泌乳大鼠的乳腺切片中,钒酸盐使通过磷酸戊糖途径的葡萄糖氧化速率提高了36%,并使通过糖酵解的葡萄糖通量提高了47%。此外,钒酸盐使果糖2,6-二磷酸(Fru-2,6-P2)水平提高了33%。将钒酸盐对葡萄糖氧化的作用与胰岛素的作用进行了比较。目前的数据表明,0.5mM钒酸盐对葡萄糖利用的作用与胰岛素相似,但未达到相同水平。

相似文献

1
Vanadate activates pentose phosphate pathway and glycolysis, and raises fructose 2,6-bisphosphate concentration in slices of lactating rat mammary gland.钒酸盐可激活戊糖磷酸途径和糖酵解,并提高泌乳期大鼠乳腺切片中果糖2,6 -二磷酸的浓度。
Biochem Int. 1991 Aug;24(6):1111-8.
2
Vanadate raises fructose 2,6-bisphosphate concentrations and activates glycolysis in rat hepatocytes.钒酸盐可提高大鼠肝细胞中果糖2,6-二磷酸的浓度并激活糖酵解。
Biochem J. 1988 Oct 15;255(2):507-12.
3
Comparative effects of insulin and proinsulin in vitro on pathways of glucose utilization and lipid synthesis in the lactating rat mammary gland.胰岛素和胰岛素原在体外对泌乳大鼠乳腺葡萄糖利用途径和脂质合成的比较作用。
Biochem Biophys Res Commun. 1988 Jul 15;154(1):443-9. doi: 10.1016/0006-291x(88)90706-1.
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[Effect of insulin on respiration of rat mammary gland sections].[胰岛素对大鼠乳腺切片呼吸的影响]
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Effect of oestradiol on the carbohydrate metabolism of immature rat uterus: the role of fructose-2, 6-bis-phosphate and of phosphoribosyl pyrophosphate.雌二醇对未成熟大鼠子宫碳水化合物代谢的影响:果糖-2,6-二磷酸和磷酸核糖焦磷酸的作用
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Vanadate treatment increases the activity of glycolytic enzymes and raises fructose 2,6-bisphosphate concentration in hearts from diabetic rats.钒酸盐处理可增加糖尿病大鼠心脏中糖酵解酶的活性,并提高果糖2,6 -二磷酸的浓度。
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Effects of vanadate on 6-phosphofructo 2-kinase activity and fructose 2,6-bisphosphate levels in cultured rat hepatocytes.钒酸盐对培养的大鼠肝细胞中6-磷酸果糖-2-激酶活性及果糖-2,6-二磷酸水平的影响。
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[The effect of vitamin K on the activity of glycolysis and pentose phosphate cycle enzymes].[维生素K对糖酵解和磷酸戊糖途径酶活性的影响]
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