岛叶皮质损伤不能阻止大鼠的味觉和味道偏好学习。
Insular cortex lesions fail to block flavor and taste preference learning in rats.
作者信息
Touzani Khalid, Sclafani Anthony
机构信息
Department of Psychology, Brooklyn College and The Graduate School, City University of New York, Brooklyn, NY 11210, USA.
出版信息
Eur J Neurosci. 2007 Sep;26(6):1692-700. doi: 10.1111/j.1460-9568.2007.05798.x. Epub 2007 Sep 6.
Abstract
The role of the insular cortex (IC) in learning to associate orosensory cues with the oral and post-oral properties of carbohydrate was examined. Rats with either small (gustatory region) or large (gustatory and visceral regions) ibotenic acid lesions of the IC learned to prefer flavors (Experiments 1 and 3) and taste mixtures (Experiments 2 and 4) paired with intragastric infusions of maltodextrin. The rats with large IC lesions also learned a preference for a flavor cue paired with the sweet taste of fructose (Experiment 5). In fact, they showed enhanced conditioning and retarded extinction compared with controls. Collectively, these data provided no evidence that IC is essential for flavor preference learning based on associations between the orosensory cues and the oral and post-oral reinforcing properties of nutrients.
摘要
研究了岛叶皮质（IC）在学习将口面部感觉线索与碳水化合物的口腔及口腔后特性建立关联中的作用。患有IC小范围（味觉区域）或大范围（味觉和内脏区域）鹅膏蕈氨酸损伤的大鼠学会了偏好与胃内注入麦芽糊精配对的味道（实验1和3）以及味道混合物（实验2和4）。患有IC大范围损伤的大鼠还学会了偏好与果糖甜味配对的味道线索（实验5）。事实上，与对照组相比，它们表现出更强的条件作用和延迟消退。总体而言，这些数据没有提供证据表明IC对于基于口面部感觉线索与营养素的口腔及口腔后强化特性之间关联的味道偏好学习至关重要。
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