Van geertruyden Jean-Pierre, D'Alessandro Umberto
Department Parasitology, Unit of Epidemiology, Institute of Tropical Medicine, Nationalestraat 155, B-2000 Antwerp, Belgium.
Trends Parasitol. 2007 Oct;23(10):465-7. doi: 10.1016/j.pt.2007.08.006. Epub 2007 Sep 6.
HIV and malaria are leading causes of morbidity in sub-Saharan Africa. Recently, Abu-Raddad and colleagues explored the synergy between these diseases through a mathematical model that included all documented interactions. It emerges from the model parameter inputs that concomitant infection of both HIV and malaria fuels the spread of both diseases. For the first time, it is shown that, according to the model, transient but repeatedly elevated HIV viral loads due to recurrent co-infections, such as malaria, can also influence and increase HIV prevalence. Probably, these results are conservative and the true impact of the interaction could be even more important.
艾滋病毒和疟疾是撒哈拉以南非洲地区发病的主要原因。最近，阿布-拉达德及其同事通过一个包含所有已记录相互作用的数学模型，探究了这两种疾病之间的协同作用。从模型参数输入中可以看出，艾滋病毒和疟疾的合并感染会助长这两种疾病的传播。该模型首次表明，由于反复合并感染（如疟疾）导致的艾滋病毒病毒载量短暂但反复升高，也会影响并增加艾滋病毒的流行率。这些结果可能较为保守，这种相互作用的实际影响可能更为重要。
