Kurepa Jasmina, Smalle Jan A
Plant Physiology, Biochemistry and Molecular Biology Program, Department of Plant and Soil Sciences, KTRDC, University of Kentucky, Lexington, KY 40546, USA.
Biochimie. 2008 Feb;90(2):324-35. doi: 10.1016/j.biochi.2007.07.019. Epub 2007 Jul 31.
Proteasomes are large multisubunit, multicatalytic proteases responsible for most of the cytosolic and nuclear protein degradation, and their structure and functions are conserved in eukaryotes. Proteasomes were originally identified as the proteolytic module of the ubiquitin-dependent proteolysis pathway. Today we know that proteasomes also mediate ubiquitin-independent proteolysis, that they have RNAse activity, and play a non-proteolytic role in transcriptional regulation. Here we present an overview of the current knowledge of proteasome function and regulation in plants and highlight the role of proteasome-dependent protein degradation in the control of plant development and responses to the environment.
蛋白酶体是大型多亚基、多催化蛋白酶，负责大部分胞质和核蛋白的降解，其结构和功能在真核生物中保守。蛋白酶体最初被鉴定为泛素依赖性蛋白水解途径的蛋白水解模块。如今我们知道，蛋白酶体也介导非泛素依赖性蛋白水解，具有核糖核酸酶活性，并在转录调控中发挥非蛋白水解作用。本文概述了目前关于植物蛋白酶体功能和调控的知识，并强调了蛋白酶体依赖性蛋白降解在植物发育控制和环境响应中的作用。
