Moiseeva T N, Mittenberg A G, Barlev N A
Tsitologiia. 2010;52(3):195-203.
26S proteasome is a multisubunit protein complex that plays a pivotal role in protein degradation. Proteasome's enzymatic activities--proteolytic, ATPase/helicase and RNase--can be used in regulation of multiple cellular processes. Recent studies confirm the major role of proteasomes in transcriptional regulation. Although various post-translational modifications of proteasome subunits have been described, relatively little is known about their functional effect on regulation of proteasome-dependent gene expression. In this article, we talk about the role of proteasomes in control of gene expression and different stages of transcription.
26S蛋白酶体是一种多亚基蛋白质复合物，在蛋白质降解中起关键作用。蛋白酶体的酶活性——蛋白水解、ATP酶/解旋酶和核糖核酸酶——可用于调节多种细胞过程。最近的研究证实了蛋白酶体在转录调控中的主要作用。尽管已经描述了蛋白酶体亚基的各种翻译后修饰，但关于它们对蛋白酶体依赖性基因表达调控的功能影响却知之甚少。在本文中，我们讨论了蛋白酶体在基因表达控制和转录不同阶段中的作用。
