非肥胖阻塞性睡眠呼吸暂停儿童的全身炎症反应
Systemic inflammation in non-obese children with obstructive sleep apnea.
作者信息
Gozal David, Serpero Laura D, Sans Capdevila Oscar, Kheirandish-Gozal Leila
机构信息
Division of Pediatric Sleep Medicine and Kosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA.
出版信息
Sleep Med. 2008 Mar;9(3):254-9. doi: 10.1016/j.sleep.2007.04.013. Epub 2007 Sep 6.
BACKGROUND
Obstructive sleep apnea (OSA) has been associated with increased systemic inflammatory responses that may contribute to an increased risk for end-organ morbidity. The changes in levels of pro-inflammatory cytokine IL-6 , and the anti-inflammatory cytokine IL-10, both of which play a major role in atherogenesis, a major consequence of OSA, have not specifically been assessed in pediatric patients.
METHODS
Consecutive non-obese children (aged 4-9years) who were polysomnographically diagnosed with OSA, and age-, gender-, ethnicity-, and BMI-matched control children underwent a blood draw the next morning after a sleep study and plasma samples were assayed for interleukins 6 (IL-6) and 10 (IL-10). These tests were repeated 4-6months after tonsillectomy and adenoidectomy (T&A) in children with OSA.
RESULTS
IL-6 levels were higher and IL-10 plasma levels were lower in children with OSA and returned to control levels after T&A.
CONCLUSIONS
Systemic inflammation is a constitutive component and consequence of OSA in many children, even in the absence of obesity, and is reversible upon treatment in most patients.
背景
阻塞性睡眠呼吸暂停（OSA）与全身炎症反应增加有关，这可能会增加终末器官发病的风险。促炎细胞因子白细胞介素-6（IL-6）和抗炎细胞因子白细胞介素-10（IL-10）水平的变化在动脉粥样硬化形成过程中起主要作用，动脉粥样硬化是OSA的主要后果之一，但尚未在儿科患者中进行专门评估。
方法
连续纳入经多导睡眠图诊断为OSA的非肥胖儿童（4-9岁），以及年龄、性别、种族和体重指数相匹配的对照儿童，在睡眠研究后的第二天早晨进行采血，并检测血浆样本中的白细胞介素-6（IL-6）和白细胞介素-10（IL-10）。对患有OSA的儿童在扁桃体切除术和腺样体切除术（T&A）后4-6个月重复这些检测。
结果
OSA儿童的IL-6水平较高，IL-10血浆水平较低，并在T&A后恢复到对照水平。
结论
全身炎症是许多儿童OSA的固有组成部分和后果，即使在没有肥胖的情况下也是如此，并且在大多数患者中治疗后是可逆的。
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