Moscoso Juan, Crawford Michael H, Vicario Jose L, Zlojutro Mark, Serrano-Vela Juan I, Reguera Raquel, Arnaiz-Villena Antonio
Department of Immunology, Universidad Complutense, The Madrid Regional Blood Center, Madrid, Spain.
Mol Immunol. 2008 Feb;45(4):1018-26. doi: 10.1016/j.molimm.2007.07.024. Epub 2007 Sep 7.
Aleuts HLA profile has been compared with that of neighboring and worldwide populations. Thirteen thousand one hundred and sixty-four chromosomes have been used for this study. Computer programs have obtained HLA allele frequencies, genetic distances between populations, NJ relatedness dendrograms, correspondence analysis and most frequent HLA extended haplotypes. Aleuts have inhabited Aleutian Islands since about 9000 years BP according to fossil and genetic (mtDNA) records. They are genetically different to Eskimo, Amerindian and Na-Dene speakers according to their HLA profile; this correlates with cultural and anthropological Aleut distinctiveness. No typical Amerindian HLA alleles have been found in a significant frequency. Their HLA relatedness to Saami (or Lapps, northern Scandinavians), Finns and Pomors (North-West Russia) indicates an ancient possible origin from the Baikal Lake Area (southern Siberia) around the present day Buryat peopling area; other origins are not discarded. Aleuts characteristic HLA profile may influence future transplantation programs in the region and be useful to study diseases linked to HLA epidemiology.
阿留申人的人类白细胞抗原（HLA）谱已与邻近人群及全球人群的谱进行了比较。本研究使用了13164条染色体。计算机程序得出了HLA等位基因频率、人群间的遗传距离、邻接法（NJ）亲缘关系树状图、对应分析以及最常见的HLA扩展单倍型。根据化石和基因（线粒体DNA）记录，阿留申人自约公元前9000年起就居住在阿留申群岛。从其HLA谱来看，他们在基因上与爱斯基摩人、美洲印第安人和讲纳-德内语的人不同；这与阿留申人在文化和人类学上的独特性相关。未发现有显著频率的典型美洲印第安HLA等位基因。他们与萨米人（或拉普人，斯堪的纳维亚北部人）、芬兰人和波莫尔人（俄罗斯西北部）的HLA亲缘关系表明，其古代起源可能在现今布里亚特人聚居区附近的贝加尔湖地区（西伯利亚南部）；也不排除有其他起源。阿留申人特有的HLA谱可能会影响该地区未来的移植项目，并有助于研究与HLA流行病学相关的疾病。
