Lemmer Björn
Institute of Pharmacology and Toxicology, University of Heidelberg, Maybachstrasse 14, D-68169 Mannheim, Germany.
Adv Drug Deliv Rev. 2007 Aug 31;59(9-10):825-7. doi: 10.1016/j.addr.2007.08.001. Epub 2007 Aug 9.
All functions in man are highly organized in time as biological rhythms of diverse periods, both in health and in disease. This represents a challenge for those involved in the development of drug-delivery systems to make possible the treatment of illness according to these physiological biological rhythms as a means of improving therapeutic outcomes. Though constant-release drug-delivery systems seem to improve patient compliance to many diverse treatments (e.g., for hypertension), rhythmicity in biological functions and in the mechanisms of disease should be mirrored by respective drug-release programs.
在健康和疾病状态下，人体的所有功能都作为不同周期的生物节律在时间上高度有序。这对参与药物递送系统开发的人员来说是一项挑战，即要根据这些生理生物节律来实现疾病治疗，以此作为改善治疗效果的一种手段。尽管缓释药物递送系统似乎能提高患者对多种不同治疗（如高血压治疗）的依从性，但生物功能和疾病机制中的节律性应通过相应的药物释放程序来体现。
