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剖析自闭症患者的执行功能缺陷:对认知神经科学的启示

Deconstructing executive deficits among persons with autism: implications for cognitive neuroscience.

作者信息

Russo Natalie, Flanagan Tara, Iarocci Grace, Berringer Darlene, Zelazo Philip David, Burack Jacob A

机构信息

Department of Educational Psychology, McGill University, Montreal, QC, Canada.

出版信息

Brain Cogn. 2007 Oct;65(1):77-86. doi: 10.1016/j.bandc.2006.04.007. Epub 2007 Sep 7.

Abstract

Individuals with autism demonstrate impairments on measures of executive function (EF) relative to typically developing comparison participants. EF is comprised of several processes including inhibition, working memory and set shifting that develop throughout the lifespan. Impairments in EF may appear early in development and persist, or may represent a more transient delay which resolves with time. Given the unevenness of the cognitive profile of persons with autism, understanding the development of EF poses methodological challenges. These issues include those related to matching measures and the choice of comparison participants to which the performance of persons with autism will be compared. In the current review, we attempt to break down the processes of inhibition, working memory and set shifting among persons with autism. We propose to do this within a developmental perspective that highlights how matching measures and comparison participants can affect the interpretation of research findings.

摘要

与发育正常的对照参与者相比,自闭症患者在执行功能(EF)测量方面表现出损伤。执行功能由包括抑制、工作记忆和定势转移在内的几个过程组成,这些过程在整个生命周期中发展。执行功能损伤可能在发育早期出现并持续存在,或者可能代表一种随着时间推移而解决的更短暂的延迟。鉴于自闭症患者认知概况的不均衡性,理解执行功能的发展带来了方法上的挑战。这些问题包括与匹配测量以及选择将与自闭症患者表现进行比较的对照参与者相关的问题。在当前的综述中,我们试图剖析自闭症患者的抑制、工作记忆和定势转移过程。我们建议在一个发展的视角内进行此操作,该视角强调匹配测量和对照参与者如何能够影响研究结果的解释。

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