Ellis-Behnke Rutledge
MIT, Brain and Cognitive Sciences, 46-6007, 43 Vassar Street, Cambridge, MA 02139, USA.
Med Clin North Am. 2007 Sep;91(5):937-62. doi: 10.1016/j.mcna.2007.04.005.
True nanomaterials are delivered as a specific structure, or combination of structures, designed to deliver the therapeutic intact, directly to the site, requiring a much lower dose. These materials use very specific and deliberate molecular structures that can interact with neurons or protein structures inside the cells. Until recently, functional recovery of the central nervous system (CNS) was an unattainable goal and nanotechnology was an invisible science. A well-planned treatment spaced over time will produce functional return in the CNS. The four P's of CNS regeneration is a new framework for approaching CNS injury and evidence shows that nanotechnology is currently being used for stroke rehabilitation and, in several clinical trials, the treatment of scar formation blockade in the spinal cord. The four components are preserve, permit, promote, and plasticity.
真正的纳米材料是以特定结构或结构组合的形式递送的，旨在完整地将治疗剂直接递送至靶点，所需剂量要低得多。这些材料采用非常特殊且经过精心设计的分子结构，能够与细胞内的神经元或蛋白质结构相互作用。直到最近，中枢神经系统（CNS）的功能恢复仍是一个无法实现的目标，而纳米技术也还是一门不为人知的科学。经过合理规划、分阶段进行的治疗将使中枢神经系统产生功能恢复。中枢神经系统再生的四个“P”是处理中枢神经系统损伤的一个新框架，有证据表明纳米技术目前正用于中风康复，并且在一些临床试验中用于治疗脊髓瘢痕形成的阻断。这四个组成部分是保存、允许、促进和可塑性。
