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纳米管突破:揭示碳纳米管作为治疗阿尔茨海默病和脑肿瘤的双重治疗武器的潜力。

Nanotube breakthroughs: unveiling the potential of carbon nanotubes as a dual therapeutic arsenal for Alzheimer's disease and brain tumors.

作者信息

Elsori Deena, Rashid Gowhar, Khan Nihad Ashraf, Sachdeva Punya, Jindal Riya, Kayenat Falak, Sachdeva Bhuvi, Kamal Mohammad Azhar, Babker Asaad Ma, Fahmy Sherif Ashraf

机构信息

Faculty of Resillience, Deans Office Rabdan Academy, Abu Dhabi, United Arab Emirates.

Amity Medical School, Amity University Gurgaon, Haryana, India.

出版信息

Front Oncol. 2023 Sep 20;13:1265347. doi: 10.3389/fonc.2023.1265347. eCollection 2023.

Abstract

Alzheimer's disease (AD) and brain tumors are debilitating neurological conditions that pose significant challenges in current medical practices. Existing treatment options for AD primarily focus on symptom management, and brain tumors often require aggressive therapeutic approaches. Novel disease-modifying strategies and therapeutic agents are urgently needed to address the underlying causes of AD pathogenesis and improve brain tumor management. In recent years, nanoparticles (NPs) have shown promise as valuable tools in diagnosing and managing various brain disorders, including AD. Among these, carbon nanotubes (CNTs) have garnered attention for their unique properties and biomedical potential. Their ability to cross the blood-brain barrier (BBB) with ease opens up new possibilities for targeted drug delivery and neuroprotection. This literature review aims to explore the versatile nature of CNTs, which can be functionalized with various biomolecules or substances due to their sp2 hybridization. This adaptability enables them to specifically target cells and deliver medications under specific environmental conditions. Moreover, CNTs possess an exceptional capacity to penetrate cell membranes, making them valuable tools in the treatment of AD and brain tumors. By delving into the role of CNTs in biomedicine, this review sheds light on their potential in managing AD, offering a glimpse of hope for effective disease-modifying options. Understanding the mechanisms of CNTs' action and their capabilities in targeting and delivering medication to affected cells will pave the way for innovative therapeutic strategies that can improve the lives of those afflicted with these devastating neurological conditions. The exploration of CNTs as a dual therapeutic arsenal for both brain tumors and Alzheimer's disease holds great promise and may usher in a new era of effective treatment strategies for these challenging conditions.

摘要

阿尔茨海默病(AD)和脑肿瘤是使人衰弱的神经系统疾病,给当前的医疗实践带来了重大挑战。AD现有的治疗方案主要集中在症状管理上,而脑肿瘤通常需要积极的治疗方法。迫切需要新的疾病修饰策略和治疗药物来解决AD发病机制的根本原因,并改善脑肿瘤的治疗。近年来,纳米颗粒(NPs)已显示出有望成为诊断和管理包括AD在内的各种脑部疾病的有价值工具。其中,碳纳米管(CNTs)因其独特的性质和生物医学潜力而受到关注。它们能够轻松穿过血脑屏障(BBB),为靶向药物递送和神经保护开辟了新的可能性。这篇文献综述旨在探讨碳纳米管的多功能性质,由于其sp2杂化,碳纳米管可以用各种生物分子或物质进行功能化。这种适应性使它们能够在特定环境条件下特异性地靶向细胞并递送药物。此外,碳纳米管具有非凡的穿透细胞膜的能力,使其成为治疗AD和脑肿瘤的有价值工具。通过深入研究碳纳米管在生物医学中的作用,本综述揭示了它们在管理AD方面的潜力,为有效的疾病修饰选择带来了一线希望。了解碳纳米管的作用机制及其靶向和向受影响细胞递送药物的能力,将为创新治疗策略铺平道路,这些策略可以改善患有这些毁灭性神经系统疾病的患者的生活。将碳纳米管作为脑肿瘤和阿尔茨海默病的双重治疗武器进行探索具有巨大的前景,可能会开创这些具有挑战性疾病的有效治疗策略的新时代。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f41e/10548133/c0f37a6f09a9/fonc-13-1265347-g001.jpg

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