Barnholtz-Sloan Jill S, Maldonado John L, Pow-sang Julio, Giuliano Anna R
Division of Cancer Prevention and Control, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Urol Oncol. 2007 Sep-Oct;25(5):361-7. doi: 10.1016/j.urolonc.2006.08.029.
To examine trends in the incidence of primary, malignant penile cancer in the United States.
A total of 1,817 men with primary, malignant penile cancer diagnosed between 1973 and 2002 from the Surveillance, Epidemiology and End Results Program Public-use data were used for analysis. Incidence rates were calculated by clinical and demographic variables of interest and decade of diagnosis (1973-1982, 1983-1992, and 1993-2002) using Surveillance, Epidemiology and End Results-Stat 6.1, and trends were examined using the annual percent change statistic. Additional incidence calculations were performed to examine further racial/ethnic differences.
The overall incidence of primary, malignant penile cancer from 1973 to 2002 was 0.69 per 100,000. Incidence decreased significantly over time: 0.84 per 100,000 in 1973-1982 to 0.69 per 100,000 in 1982-1992 to 0.58 per 100,000 in 1993-2002. Incidence increased with increasing age at diagnosis. The majority of cases had squamous cell carcinomas, graded as I or II, and originated at the glans penis. Incidence of unknown grade primary, malignant penile cancer decreased significantly over the last 30 years, as did incidence of primary site penis, not otherwise specified primary, malignant penile cancer. The incidence of regional stage disease also increased over time. From 1993 to 2002, White Hispanics had the highest incidence rates (1.01 per 100,000) followed by Alaska Native/American Indians (0.77 per 100,000) and Blacks (0.62 per 100,000).
The overall incidence of primary, malignant penile cancer in the United States has decreased, and these rates varied by race/ethnicity. Incidence rates increased with increasing age at diagnosis, and the incidence of regional stage disease increased over time, while incidence of unknown grade primary, malignant penile cancer decreased over the last 30 years.
研究美国原发性恶性阴茎癌的发病率趋势。
利用监测、流行病学和最终结果计划（Surveillance, Epidemiology and End Results Program）公开数据中1973年至2002年间确诊的1817例原发性恶性阴茎癌男性患者进行分析。使用监测、流行病学和最终结果统计软件6.1（Surveillance, Epidemiology and End Results-Stat 6.1），根据感兴趣的临床和人口统计学变量以及诊断年代（1973 - 1982年、1983 - 1992年和1993 - 2002年）计算发病率，并使用年度百分比变化统计量来研究趋势。进行了额外的发病率计算以进一步研究种族/民族差异。
1973年至2002年原发性恶性阴茎癌的总体发病率为每10万人0.69例。发病率随时间显著下降：1973 - 1982年为每10万人0.84例，1983 - 1992年为每10万人0.69例，1993 - 2002年为每10万人0.58例。发病率随诊断时年龄的增加而上升。大多数病例为鳞状细胞癌，分级为I或II级，起源于阴茎头。在过去30年中，未知分级的原发性恶性阴茎癌发病率以及未另行指定原发性部位的阴茎原发性恶性阴茎癌发病率均显著下降。区域分期疾病的发病率也随时间增加。1993年至2002年，西班牙裔白人发病率最高（每10万人1.01例），其次是阿拉斯加原住民/美洲印第安人（每10万人0.77例）和黑人（每10万人0.62例）。
美国原发性恶性阴茎癌的总体发病率有所下降，且这些发病率因种族/民族而异。发病率随诊断时年龄的增加而上升，区域分期疾病的发病率随时间增加，而在过去30年中未知分级的原发性恶性阴茎癌发病率下降。
