Department of Medical Oncology, Ankara University Faculty of Medicine, 06620 Ankara, Türkiye.
Faculty of Medicine, Department of Internal Medicine, Division of Internal Medicine, Ankara University Cancer Research Institute, 06620 Ankara, Türkiye.
Viruses. 2024 Apr 25;16(5):667. doi: 10.3390/v16050667.
Human papillomavirus (HPV), an oncogenic DNA virus, is the most common sexually transmitted virus and significant public health concern globally. Despite the substantial prevalence of HPV infection among men, routine testing remains elusive due to the lack of approved HPV tests and the complexity of detection methods. Various studies have explored the link between HPV and genitourinary cancers, revealing different associations influenced by geographic variation, histological subtype and methodological differences. These findings underscore the importance of further research to elucidate the role of HPV in male urogenital cancers. This comprehensive review delves into the intricate relationship between HPV and male genitourinary cancers, shedding light on the virus's oncogenic mechanisms and its reported prevalence. A deeper understanding of HPV's implications for male health is essential for advancing public health initiatives and reducing the burden of urogenital cancers worldwide.
人乳头瘤病毒（HPV）是一种致癌 DNA 病毒，是全球最常见的性传播病毒，也是一个重大的公共卫生关注问题。尽管 HPV 在男性中的感染率相当高，但由于缺乏批准的 HPV 检测和检测方法的复杂性，常规检测仍然难以实现。多项研究探讨了 HPV 与泌尿生殖系统癌症之间的联系，揭示了不同的关联，这些关联受到地理变异、组织学亚型和方法学差异的影响。这些发现强调了进一步研究的重要性，以阐明 HPV 在男性泌尿生殖系统癌症中的作用。本综述深入探讨了 HPV 与男性泌尿生殖系统癌症之间的复杂关系，阐明了病毒的致癌机制及其报道的流行率。深入了解 HPV 对男性健康的影响对于推进公共卫生计划和减轻全球泌尿生殖系统癌症负担至关重要。
