Department of Otorhinolaryngology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.
Eur Arch Otorhinolaryngol. 2011 Apr;268(4):497-500. doi: 10.1007/s00405-010-1400-2. Epub 2010 Nov 3.
The aim of this study is to develop a regression model for predicting hearing outcome in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). A total of 174 consecutive patients with ISSNHL (average of the hearing levels at 250, 500, 1,000, 2,000, and 4,000 Hz was ≥40 dB; time from onset to treatment was ≤30 days) were retrospectively analyzed. They received steroid administration (400 mg/day of hydrocortisone sodium succinate followed by tapered doses) in combination with hyperbaric oxygen therapy. The hearing improvement rate compared to the unaffected contralateral ear was calculated. Correlations between the hearing improvement rate and four prognostic factors (patient's age, days from onset to treatment, initial hearing level, and the presence of vertigo) were examined by simple and multiple regression analyses. In the simple regression analysis, significant correlations were observed between the hearing improvement rate and all four prognostic factors. In the multiple regression analysis, the correlation was significant for patient's age, days from onset to treatment, and the presence of vertigo with partial correlation coefficients of -0.221, -0.324, and -0.329, respectively, but was not significant for the initial hearing level. We subsequently formulated a multiple regression equation for predicting the hearing improvement rate. The multiple correlation coefficient was 0.495 with a p value of 1.42 × 10(-9). Using this regression model, the hearing improvement rate is still difficult to predict with 95% probability, but is predictable with 70% probability.
本研究旨在建立一个预测特发性突发性聋（ISSNHL）患者听力预后的回归模型。回顾性分析了 174 例连续的 ISSNHL 患者（平均听力水平在 250、500、1000、2000 和 4000Hz 处≥40dB；发病至治疗时间≤30 天）。他们接受了皮质类固醇（400mg/天琥珀酸钠氢可酮，然后逐渐减少剂量）联合高压氧治疗。与对侧未受影响的耳朵相比，计算听力改善率。通过简单和多元回归分析，检查听力改善率与四个预后因素（患者年龄、发病至治疗的天数、初始听力水平和眩晕的存在）之间的相关性。在简单回归分析中，听力改善率与所有四个预后因素均呈显著相关。在多元回归分析中，患者年龄、发病至治疗的天数和眩晕的存在与部分相关系数分别为-0.221、-0.324 和-0.329 相关，而初始听力水平无显著相关性。我们随后制定了一个预测听力改善率的多元回归方程。多元相关系数为 0.495，p 值为 1.42×10(-9)。使用该回归模型，听力改善率仍难以用 95%的概率预测，但有 70%的概率可以预测。
